Sequence of EASG_CLAP2
EC Number:1.5.1.46
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
agroclavine + NADP+ = 6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH + H+
Other sequences found for EC No. 1.5.1.46
General information:
Sequence
0 MTVLLTGGTG RTAKHIAGIF RQTNVPFLVA SRSSSAGTAE NHRKFDWLDE ETFPNALSVD
60 QGMKPISVVW LCPPPLYDLA TPVIKFIDFA VSQNVKKFVL LSASVIQKGG PAMGKIHEHL
120 DSIKDVTYTV LRPTWFMENF STKGEIQCEA IRRDSTVYSA TENGKIPFIS VVDIARVAAC
180 ALTAETLKNS DHILQGPDLL TYDEVAQALT GVLGRKITHT KMTEGELAEK LMEEGVTPEE
240 AYMHAAMDSM IKSGSEERVV SDEVKAWTGV KPRGFINFAL SEKAAWRARK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
666118
Schardl C.L.,Young C.A.,Hesse U.,Amyotte S.G.,Andreeva K.,Calie P.J.,Fleetwood D.J.,Haws D.C.,Moore N.,Oeser B.,Panaccione D.G.,Schweri K.K.,Voisey C.R.,Farman M.L.,Jaromczyk J.W.,Roe B.A.,O'Sullivan D.M.,Scott B.,Tudzynski P.,An Z.,Arnaoudova E.G.,Bullock C.T.,Charlton N.D.,Chen L.,Cox M.,Dinkins R.D.,Florea S.,Glenn A.E.,Gordon A.,Gueldener U.,Harris D.R.,Hollin W.,Jaromczyk J.,Johnson R.D.,Khan A.K.,Leistner E.,Leuchtmann A.,Li C.,Liu J.,Liu J.,Liu M.,Mace W.,Machado C.,Nagabhyru P.,Pan J.,Schmid J.,Sugawara K.,Steiner U.,Takach J.E.,Tanaka E.,Webb J.S.,Wilson E.V.,Wiseman J.L.,Yoshida R.,Zeng Z.
Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the Clavicipitaceae reveals dynamics of alkaloid loci.
PLoS Genet.
9
0-0
2013
666119
Tudzynski P.,Correia T.,Keller U.
Biotechnology and genetics of ergot alkaloids.
Appl. Microbiol. Biotechnol.
57
593-605
2001
666120
Correia T.,Grammel N.,Ortel I.,Keller U.,Tudzynski P.
Molecular cloning and analysis of the ergopeptine assembly system in the ergot fungus Claviceps purpurea.
Chem. Biol.
10
1281-1292
2003
666121
Wang J.,Machado C.,Panaccione D.G.,Tsai H.-F.,Schardl C.L.
The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass.
Fungal Genet. Biol.
41
189-198
2004
666122
Haarmann T.,Machado C.,Lubbe Y.,Correia T.,Schardl C.L.,Panaccione D.G.,Tudzynski P.
The ergot alkaloid gene cluster in Claviceps purpurea: extension of the cluster sequence and intra species evolution.
Phytochemistry
66
1312-1320
2005
666123
Haarmann T.,Ortel I.,Tudzynski P.,Keller U.
Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways.
ChemBioChem
7
645-652
2006
666124
Fleetwood D.J.,Scott B.,Lane G.A.,Tanaka A.,Johnson R.D.
A complex ergovaline gene cluster in epichloe endophytes of grasses.
Appl. Environ. Microbiol.
73
2571-2579
2007
666125
Lorenz N.,Wilson E.V.,Machado C.,Schardl C.L.,Tudzynski P.
Comparison of ergot alkaloid biosynthesis gene clusters in Claviceps species indicates loss of late pathway steps in evolution of C. fusiformis.
Appl. Environ. Microbiol.
73
7185-7191
2007
666126
Haarmann T.,Lorenz N.,Tudzynski P.
Use of a nonhomologous end joining deficient strain (Deltaku70) of the ergot fungus Claviceps purpurea for identification of a nonribosomal peptide synthetase gene involved in ergotamine biosynthesis.
Fungal Genet. Biol.
45
35-44
2008
666127
Ortel I.,Keller U.
Combinatorial assembly of simple and complex D-lysergic acid alkaloid peptide classes in the ergot fungus Claviceps purpurea.
J. Biol. Chem.
284
6650-6660
2009
666128
Lorenz N.,Olsovska J.,Sulc M.,Tudzynski P.
Alkaloid cluster gene ccsA of the ergot fungus Claviceps purpurea encodes chanoclavine I synthase, a flavin adenine dinucleotide-containing oxidoreductase mediating the transformation of N-methyl-dimethylallyltryptophan to chanoclavine I.
Appl. Environ. Microbiol.
76
1822-1830
2010
666129
Cheng J.Z.,Coyle C.M.,Panaccione D.G.,O'Connor S.E.
Controlling a structural branch point in ergot alkaloid biosynthesis.
J. Am. Chem. Soc.
132
12835-12837
2010
666130
Goetz K.E.,Coyle C.M.,Cheng J.Z.,O'Connor S.E.,Panaccione D.G.
Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus.
Curr. Genet.
57
201-211
2011
666131
Matuschek M.,Wallwey C.,Xie X.,Li S.M.
New insights into ergot alkaloid biosynthesis in Claviceps purpurea: an agroclavine synthase EasG catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-I aldehyde to agroclavine.
Org. Biomol. Chem.
9
4328-4335
2011
666132
Havemann J.,Vogel D.,Loll B.,Keller U.
Cyclolization of D-lysergic acid alkaloid peptides.
Chem. Biol.
21
146-155
2014
