Sequence of AMPX_VIBPR
EC Number:3.4.11.10
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids
General information:
Sequence
0 MKYTKTLLAM VLSATFCQAY AEDKVWISIG ADANQTVMKS GAESILPNSV ASSGQVWVGQ
60 VDVAQLAELS HNMHEEHNRC GGYMVHPSAQ SAMAASAMPT TLASFVMPPI TQQATVTAWL
120 PQVDASQITG TISSLESFTN RFYTTTSGAQ ASDWIASEWQ ALSASLPNAS VKQVSHSGYN
180 QKSVVMTITG SEAPDEWIVI GGHLDSTIGS HTNEQSVAPG ADDDASGIAA VTEVIRVLSE
240 NNFQPKRSIA FMAYAAEEVG LRGSQDLANQ YKSEGKNVVS ALQLDMTNYK GSAQDVVFIT
300 DYTDSNFTQY LTQLMDEYLP SLTYGFDTCG YACSDHASWH NAGYPAAMPF ESKFNDYNPR
360 IHTTQDTLAN SDPTGSHAKK FTQLGLAYAI EMGSATGDTP TPGNQLEDGV PVTDLSGSRG
420 SNVWYTFELE TQKNLQITTS GGYGDLDLYV KFGSKASKQN WDCRPYLSGN NEVCTFNNAS
480 PGTYSVMLTG YSNYSGASLK ASTF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
675007
van Heeke G.,Denslow S.,Watkins J.,Wilson K.,Wagner F.
Cloning and nucleotide sequence of the Vibrio proteolyticus aminopeptidase gene.
Biochim. Biophys. Acta
1131
337-340
1992
675008
Guenet C.,Lepage P.,Harris B.A.
Isolation of the leucine aminopeptidase gene from Aeromonas proteolytica. Evidence for an enzyme precursor.
J. Biol. Chem.
267
8390-8395
1992
675009
Schalk C.,Remy J.M.,Chevrier B.,Moras D.,Tarnus C.
Rapid purification of the Aeromonas proteolytica aminopeptidase: crystallization and preliminary X-ray data.
Arch. Biochem. Biophys.
294
91-97
1992
675010
Chevrier B.,Schalk C.,D'Orchymont H.,Rondeau J.-M.,Moras D.,Tarnus C.
Crystal structure of Aeromonas proteolytica aminopeptidase: a prototypical member of the co-catalytic zinc enzyme family.
Structure
2
283-290
1994
675011
Chevrier B.,D'Orchymont H.,Schalk C.,Tarnus C.,Moras D.
The structure of the Aeromonas proteolytica aminopeptidase complexed with a hydroxamate inhibitor. Involvement in catalysis of Glu151 and two zinc ions of the co-catalytic unit.
Eur. J. Biochem.
237
393-398
1996
675012
De Paola C.C.,Bennett B.,Holz R.C.,Ringe D.,Petsko G.A.
1-butaneboronic acid binding to Aeromonas proteolytica aminopeptidase: a case of arrested development.
Biochemistry
38
9048-9053
1999
675013
Stamper C.,Bennett B.,Edwards T.,Holz R.C.,Ringe D.,Petsko G.A.
Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinephosphonic acid. Spectroscopic and crystallographic characterization of the transition state of peptide hydrolysis.
Biochemistry
40
7035-7046
2001
