Sequence of AAPK1_MOUSE

[acetyl-CoA carboxylase] kinase

Q5EG47

559

63929

638109

Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.

Lineage-specific biology revealed by a finished genome assembly of the mouse.

PLoS Biol.

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0-0

2009

638111

Hawley S.A.,Pan D.A.,Mustard K.J.,Ross L.,Bain J.,Edelman A.M.,Frenguelli B.G.,Hardie D.G.

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

Cell Metab.

2

9-19

2005

638112

Daval M.,Diot-Dupuy F.,Bazin R.,Hainault I.,Viollet B.,Vaulont S.,Hajduch E.,Ferre P.,Foufelle F.

Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes.

J. Biol. Chem.

280

25250-25257

2005

638113

Hurley R.L.,Anderson K.A.,Franzone J.M.,Kemp B.E.,Means A.R.,Witters L.A.

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.

J. Biol. Chem.

280

29060-29066

2005

638114

Koo S.-H.,Flechner L.,Qi L.,Zhang X.,Screaton R.A.,Jeffries S.,Hedrick S.,Xu W.,Boussouar F.,Brindle P.,Takemori H.,Montminy M.

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.

Nature

437

1109-1111

2005

638115

Shaw R.J.,Lamia K.A.,Vasquez D.,Koo S.-H.,Bardeesy N.,Depinho R.A.,Montminy M.,Cantley L.C.

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Science

310

1642-1646

2005

638116

Treebak J.T.,Glund S.,Deshmukh A.,Klein D.K.,Long Y.C.,Jensen T.E.,Jorgensen S.B.,Viollet B.,Andersson L.,Neumann D.,Wallimann T.,Richter E.A.,Chibalin A.V.,Zierath J.R.,Wojtaszewski J.F.

AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.

Diabetes

55

2051-2058

2006

638117

Kramer H.F.,Witczak C.A.,Fujii N.,Jessen N.,Taylor E.B.,Arnolds D.E.,Sakamoto K.,Hirshman M.F.,Goodyear L.J.

Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle.

Diabetes

55

2067-2076

2006

638118

Villen J.,Beausoleil S.A.,Gerber S.A.,Gygi S.P.

Large-scale phosphorylation analysis of mouse liver.

Proc. Natl. Acad. Sci. U.S.A.

104

1488-1493

2007

638119

Al-Hakim A.K.,Zagorska A.,Chapman L.,Deak M.,Peggie M.,Alessi D.R.

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains.

Biochem. J.

411

249-260

2008

638120

Gwinn D.M.,Shackelford D.B.,Egan D.F.,Mihaylova M.M.,Mery A.,Vasquez D.S.,Turk B.E.,Shaw R.J.

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Mol. Cell

30

214-226

2008

638121

Trost M.,English L.,Lemieux S.,Courcelles M.,Desjardins M.,Thibault P.

The phagosomal proteome in interferon-gamma-activated macrophages.

Immunity

30

143-154

2009

638122

Lamia K.A.,Sachdeva U.M.,DiTacchio L.,Williams E.C.,Alvarez J.G.,Egan D.F.,Vasquez D.S.,Juguilon H.,Panda S.,Shaw R.J.,Thompson C.B.,Evans R.M.

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation.

Science

326

437-440

2009

638123

Zhao J.,Yue W.,Zhu M.J.,Sreejayan N.,Du M.

AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552.

Biochem. Biophys. Res. Commun.

395

146-151

2010

638124

Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.

A tissue-specific atlas of mouse protein phosphorylation and expression.

Cell

143

1174-1189

2010

638125

Bungard D.,Fuerth B.J.,Zeng P.Y.,Faubert B.,Maas N.L.,Viollet B.,Carling D.,Thompson C.B.,Jones R.G.,Berger S.L.

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation.

Science

329

1201-1205

2010

638126

Loffler A.S.,Alers S.,Dieterle A.M.,Keppeler H.,Franz-Wachtel M.,Kundu M.,Campbell D.G.,Wesselborg S.,Alessi D.R.,Stork B.

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

Autophagy

7

696-706

2011

638127

Li Y.,Xu S.,Mihaylova M.M.,Zheng B.,Hou X.,Jiang B.,Park O.,Luo Z.,Lefai E.,Shyy J.Y.,Gao B.,Wierzbicki M.,Verbeuren T.J.,Shaw R.J.,Cohen R.A.,Zang M.

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

Cell Metab.

13

376-388

2011

638128

Kim J.,Kundu M.,Viollet B.,Guan K.L.

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

Nat. Cell Biol.

13

132-141

2011

638129

Egan D.F.,Shackelford D.B.,Mihaylova M.M.,Gelino S.,Kohnz R.A.,Mair W.,Vasquez D.S.,Joshi A.,Gwinn D.M.,Taylor R.,Asara J.M.,Fitzpatrick J.,Dillin A.,Viollet B.,Kundu M.,Hansen M.,Shaw R.J.

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Science

331

456-461

2011

638130

Peserico A.,Chiacchiera F.,Grossi V.,Matrone A.,Latorre D.,Simonatto M.,Fusella A.,Ryall J.G.,Finley L.W.,Haigis M.C.,Villani G.,Puri P.L.,Sartorelli V.,Simone C.

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

Cell. Mol. Life Sci.

70

2015-2029

2013

638131

Liu R.,Lee J.H.,Li J.,Yu R.,Tan L.,Xia Y.,Zheng Y.,Bian X.L.,Lorenzi P.L.,Chen Q.,Lu Z.

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.

Mol. Cell

81

2722-2735

2021