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Sequence of MA2B1_HUMAN

EC Number:3.2.1.24

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
alpha-mannosidase
O00754
Homo sapiens
1011
113744
Reaction
2-O-alpha-D-mannopyranosyl-D-mannopyranose + H2O = 2 alpha-D-mannopyranose
Other sequences found for EC No. 3.2.1.24

General information:

Sequence
show sequence in fasta format
   0 MGAYARASGV CARGCLDSAG PWTMSRALRP PLPPLCFFLL LLAAAGARAG GYETCPTVQP
  60 NMLNVHLLPH THDDVGWLKT VDQYFYGIKN DIQHAGVQYI LDSVISALLA DPTRRFIYVE
 120 IAFFSRWWHQ QTNATQEVVR DLVRQGRLEF ANGGWVMNDE AATHYGAIVD QMTLGLRFLE
 180 DTFGNDGRPR VAWHIDPFGH SREQASLFAQ MGFDGFFFGR LDYQDKWVRM QKLEMEQVWR
 240 ASTSLKPPTA DLFTGVLPNG YNPPRNLCWD VLCVDQPLVE DPRSPEYNAK ELVDYFLNVA
 300 TAQGRYYRTN HTVMTMGSDF QYENANMWFK NLDKLIRLVN AQQAKGSSVH VLYSTPACYL
 360 WELNKANLTW SVKHDDFFPY ADGPHQFWTG YFSSRPALKR YERLSYNFLQ VCNQLEALVG
 420 LAANVGPYGS GDSAPLNEAM AVLQHHDAVS GTSRQHVAND YARQLAAGWG PCEVLLSNAL
 480 ARLRGFKDHF TFCQQLNISI CPLSQTAARF QVIVYNPLGR KVNWMVRLPV SEGVFVVKDP
 540 NGRTVPSDVV IFPSSDSQAH PPELLFSASL PALGFSTYSV AQVPRWKPQA RAPQPIPRRS
 600 WSPALTIENE HIRATFDPDT GLLMEIMNMN QQLLLPVRQT FFWYNASIGD NESDQASGAY
 660 IFRPNQQKPL PVSRWAQIHL VKTPLVQEVH QNFSAWCSQV VRLYPGQRHL ELEWSVGPIP
 720 VGDTWGKEVI SRFDTPLETK GRFYTDSNGR EILERRRDYR PTWKLNQTEP VAGNYYPVNT
 780 RIYITDGNMQ LTVLTDRSQG GSSLRDGSLE LMVHRRLLKD DGRGVSEPLM ENGSGAWVRG
 840 RHLVLLDTAQ AAAAGHRLLA EQEVLAPQVV LAPGGGAAYN LGAPPRTQFS GLRRDLPPSV
 900 HLLTLASWGP EMVLLRLEHQ FAVGEDSGRN LSAPVTLNLR DLFSTFTITR LQETTLVANQ
 960 LREAASRLKW TTNTGPTPHQ TPYQLDPANI TLEPMEIRTF LASVQWKEVD G
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
56140
Nebes V.L.,Schmidt M.C.
Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNA.
Biochem. Biophys. Res. Commun.
200
239-245
1994
56141
Nilssen O.,Berg T.,Riise H.M.F.,Ramachandran U.,Evjen G.,Hansen G.M.,Malm D.,Tranebjaerg L.,Tollersrud O.-K.
Alpha-mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings.
Hum. Mol. Genet.
6
717-726
1997
56142
Riise H.M.F.,Berg T.,Nilssen O.,Romeo G.,Tollersrud O.-K.,Ceccherini I.
Genomic structure of the human lysosomal alpha-mannosidase gene (MANB).
Genomics
42
200-207
1997
56143
Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.
The DNA sequence and biology of human chromosome 19.
Nature
428
529-535
2004
56145
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
56146
Liao Y.-F.,Lal A.,Moremen K.W.
Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid alpha-mannosidase.
J. Biol. Chem.
271
28348-28358
1996
56147
Emiliani C.,Martino S.,Stirling J.L.,Maras B.,Orlacchio A.
Partial sequence of the purified protein confirms the identity of cDNA coding for human lysosomal alpha-mannosidase B.
Biochem. J.
305
363-366
1995
56148
Zhang H.,Li X.-J.,Martin D.B.,Aebersold R.
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
Nat. Biotechnol.
21
660-666
2003
56149
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
56150
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
56151
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
56152
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
56153
Gotoda Y.,Wakamatsu N.,Kawai H.,Nishida Y.,Matsumoto T.
Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosis.
Am. J. Hum. Genet.
63
1015-1024
1998
56154
Berg T.,Riise H.M.F.,Hansen G.M.,Malm D.,Tranebjaerg L.,Tollersrud O.-K.,Nilssen O.
Spectrum of mutations in alpha-mannosidosis.
Am. J. Hum. Genet.
64
77-88
1999
56155
Oelmez A.,Nilssen O.,Coskun T.,Klenow H.
Alpha-mannosidosis and mutational analysis in a Turkish patient.
Turk. J. Pediatr.
45
46-50
2003
56156
Sbaragli M.,Bibi L.,Pittis M.G.,Balducci C.,Heikinheimo P.,Ricci R.,Antuzzi D.,Parini R.,Spaccini L.,Bembi B.,Beccari T.
Identification and characterization of five novel MAN2B1 mutations in Italian patients with alpha-mannosidosis.
Hum. Mutat.
25
320-320
2005
56157
Riise Stensland H.M.,Klenow H.B.,Van Nguyen L.,Hansen G.M.,Malm D.,Nilssen O.
Identification of 83 novel alpha-mannosidosis-associated sequence variants: functional analysis of MAN2B1 missense mutations.
Hum. Mutat.
33
511-520
2012