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Sequence of ST2A1_HUMAN

EC Number:2.8.2.14

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
bile-salt sulfotransferase
Q06520
Homo sapiens
285
33780
Reaction
3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
Other sequences found for EC No. 2.8.2.14

General information:

Sequence
show sequence in fasta format
  0 MSDDFLWFEG IAFPTMGFRS ETLRKVRDEF VIRDEDVIIL TYPKSGTNWL AEILCLMHSK
 60 GDAKWIQSVP IWERSPWVES EIGYTALSET ESPRLFSSHL PIQLFPKSFF SSKAKVIYLM
120 RNPRDVLVSG YFFWKNMKFI KKPKSWEEYF EWFCQGTVLY GSWFDHIHGW MPMREEKNFL
180 LLSYEELKQD TGRTIEKICQ FLGKTLEPEE LNLILKNSSF QSMKENKMSN YSLLSVDYVV
240 DKAQLLRKGV SGDWKNHFTV AQAEDFDKLF QEKMADLPRE LFPWE
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
614471
Comer K.A.,Falany J.L.,Falany C.N.
Cloning and expression of human liver dehydroepiandrosterone sulphotransferase.
Biochem. J.
289
233-240
1993
614472
Otterness D.M.,Wieben E.D.,Wood T.C.,Watson R.W.G.,Madden B.J.,McCormick D.J.,Weinshilboum R.M.
Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA.
Mol. Pharmacol.
41
865-872
1992
614473
Forbes K.J.,Hagen M.,Coughtrie M.W.H.,Glatt H.R.,Hume R.
Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme.
Mol. Cell. Endocrinol.
112
53-60
1995
614474
Luu-The V.,Dufort I.,Paquet N.,Reimnitz G.,Labrie F.
Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene.
DNA Cell Biol.
14
511-518
1995
614475
Otterness D.M.,Her C.,Aksoy S.,Kimura S.,Wieben E.D.,Weinshilboum R.M.
Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization.
DNA Cell Biol.
14
331-341
1995
614476
Kong A.-N.T.,Yang L.,Ma M.,Tao D.,Bjornsson T.D.
Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver.
Biochem. Biophys. Res. Commun.
187
448-454
1992
614477
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
614478
Radominska A.,Comer K.A.,Zimniak P.,Falany J.,Iscan M.,Falany C.N.
Human liver steroid sulphotransferase sulphates bile acids.
Biochem. J.
272
597-604
1990
614479
Glatt H.,Seidel A.,Harvey R.G.,Coughtrie M.W.
Activation of benzylic alcohols to mutagens by human hepatic sulphotransferases.
Mutagenesis
9
553-557
1994
614480
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
614481
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
614482
Pedersen L.C.,Petrotchenko E.V.,Negishi M.
Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase.
FEBS Lett.
475
61-64
2000
614483
Rehse P.H.,Zhou M.,Lin S.X.
Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate.
Biochem. J.
364
165-171
2002
614484
Chang H.J.,Shi R.,Rehse P.,Lin S.X.
Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex.
J. Biol. Chem.
279
2689-2696
2004
614485
Lu L.Y.,Hsieh Y.C.,Liu M.Y.,Lin Y.H.,Chen C.J.,Yang Y.S.
Identification and characterization of two amino acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase (SULT2A1).
Mol. Pharmacol.
73
660-668
2008
614486
Cook I.T.,Duniec-Dmuchowski Z.,Kocarek T.A.,Runge-Morris M.,Falany C.N.
24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation.
Drug Metab. Dispos.
37
2069-2078
2009
614487
Gulcan H.O.,Duffel M.W.
Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes.
Arch. Biochem. Biophys.
507
232-240
2011
614488
Abunnaja M.S.,Alherz F.A.,El Daibani A.A.,Bairam A.F.,Rasool M.I.,Gohal S.A.,Kurogi K.,Suiko M.,Sakakibara Y.,Liu M.C.
Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1.
Biochem. Cell Biol.
96
655-662
2018