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Sequence of SSN3_YEAST

EC Number:2.7.11.23

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
[RNA-polymerase]-subunit kinase
P39073
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
555
62847
Reaction
ATP + [DNA-directed RNA polymerase] = ADP + phospho-[DNA-directed RNA polymerase]
Other sequences found for EC No. 2.7.11.23

General information:

Sequence
show sequence in fasta format
  0 MYNGKDRAQN SYQPMYQRPM QVQGQQQAQS FVGKKNTIGS VHGKAPMLMA NNDVFTIGPY
 60 RARKDRMRVS VLEKYEVIGY IAAGTYGKVY KAKRQINSGT NSANGSSLNG TNAKIPQFDS
120 TQPKSSSSMD MQANTNALRR NLLKDEGVTP GRIRTTREDV SPHYNSQKQT LIKKPLTVFY
180 AIKKFKTEKD GVEQLHYTGI SQSACREMAL CRELHNKHLT TLVEIFLERK CVHMVYEYAE
240 HDLLQIIHFH SHPEKRMIPP RMVRSIMWQL LDGVSYLHQN WVLHRDLKPA NIMVTIDGCV
300 KIGDLGLARK FHNMLQTLYT GDKVVVTIWY RAPELLLGAR HYTPAVDLWS VGCIFAELIG
360 LQPIFKGEEA KLDSKKTVPF QVNQLQRILE VLGTPDQKIW PYLEKYPEYD QITKFPKYRD
420 NLATWYHSAG GRDKHALSLL YHLLNYDPIK RIDAFNALEH KYFTESDIPV SENVFEGLTY
480 KYPARRIHTN DNDIMNLGSR TKNNTQASGI TAGAAANALG GLGVNRRILA AAAAAAAAVS
540 GNNASDEPSR KKNRR
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
614242
Surosky R.T.,Strich R.,Esposito R.E.
The yeast UME5 gene regulates the stability of meiotic mRNAs in response to glucose.
Mol. Cell. Biol.
14
3446-3458
1994
614243
Liao S.-M.,Zhang J.,Jeffery D.A.,Koleske A.J.,Thompson C.M.,Chao D.M.,Viljoen M.,van Vuuren H.J.J.,Young R.A.
A kinase-cyclin pair in the RNA polymerase II holoenzyme.
Nature
374
193-196
1995
614244
Bussey H.,Storms R.K.,Ahmed A.,Albermann K.,Allen E.,Ansorge W.,Araujo R.,Aparicio A.,Barrell B.G.,Badcock K.,Benes V.,Botstein D.,Bowman S.,Brueckner M.,Carpenter J.,Cherry J.M.,Chung E.,Churcher C.M.,Coster F.,Davis K.,Davis R.W.,Dietrich F.S.,Delius H.,DiPaolo T.,Dubois E.,Duesterhoeft A.,Duncan M.,Floeth M.,Fortin N.,Friesen J.D.,Fritz C.,Goffeau A.,Hall J.,Hebling U.,Heumann K.,Hilbert H.,Hillier L.W.,Hunicke-Smith S.,Hyman R.W.,Johnston M.,Kalman S.,Kleine K.,Komp C.,Kurdi O.,Lashkari D.,Lew H.,Lin A.,Lin D.,Louis E.J.,Marathe R.,Messenguy F.,Mewes H.-W.,Mirtipati S.,Moestl D.,Mueller-Auer S.,Namath A.,Nentwich U.,Oefner P.,Pearson D.,Petel F.X.,Pohl T.M.,Purnelle B.,Rajandream M.A.,Rechmann S.,Rieger M.,Riles L.,Roberts D.,Schaefer M.,Scharfe M.,Scherens B.,Schramm S.,Schroeder M.,Sdicu A.-M.,Tettelin H.,Urrestarazu L.A.,Ushinsky S.,Vierendeels F.,Vissers S.,Voss H.,Walsh S.V.,Wambutt R.,Wang Y.,Wedler E.,Wedler H.,Winnett E.,Zhong W.-W.,Zollner A.,Vo D.H.,Hani J.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Nature
387
103-105
1997
614245
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
614246
Holstege F.C.P.,Jennings E.G.,Wyrick J.J.,Lee T.I.,Hengartner C.J.,Green M.R.,Golub T.R.,Lander E.S.,Young R.A.
Dissecting the regulatory circuitry of a eukaryotic genome.
Cell
95
717-728
1998
614247
Hengartner C.J.,Myer V.E.,Liao S.-M.,Wilson C.J.,Koh S.S.,Young R.A.
Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases.
Mol. Cell
2
43-53
1998
614248
Hirst M.,Kobor M.S.,Kuriakose N.,Greenblatt J.,Sadowski I.
GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8.
Mol. Cell
3
673-678
1999
614249
Chi Y.,Huddleston M.J.,Zhang X.,Young R.A.,Annan R.S.,Carr S.A.,Deshaies R.J.
Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase.
Genes Dev.
15
1078-1092
2001
614250
Kang J.S.,Kim S.H.,Hwang M.S.,Han S.J.,Lee Y.C.,Kim Y.-J.
The structural and functional organization of the yeast mediator complex.
J. Biol. Chem.
276
42003-42010
2001
614251
Zaman Z.,Ansari A.Z.,Koh S.S.,Young R.,Ptashne M.
Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression.
Proc. Natl. Acad. Sci. U.S.A.
98
2550-2554
2001
614252
Borggrefe T.,Davis R.,Erdjument-Bromage H.,Tempst P.,Kornberg R.D.
A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast.
J. Biol. Chem.
277
44202-44207
2002
614253
Nelson C.,Goto S.,Lund K.,Hung W.,Sadowski I.
Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12.
Nature
421
187-190
2003
614254
Bourbon H.-M.,Aguilera A.,Ansari A.Z.,Asturias F.J.,Berk A.J.,Bjoerklund S.,Blackwell T.K.,Borggrefe T.,Carey M.,Carlson M.,Conaway J.W.,Conaway R.C.,Emmons S.W.,Fondell J.D.,Freedman L.P.,Fukasawa T.,Gustafsson C.M.,Han M.,He X.,Herman P.K.,Hinnebusch A.G.,Holmberg S.,Holstege F.C.P.,Jaehning J.A.,Kim Y.-J.,Kuras L.,Leutz A.,Lis J.T.,Meisterernest M.,Naeaer A.M.,Nasmyth K.,Parvin J.D.,Ptashne M.,Reinberg D.,Ronne H.,Sadowski I.,Sakurai H.,Sipiczki M.,Sternberg P.W.,Stillman D.J.,Strich R.,Struhl K.,Svejstrup J.Q.,Tuck S.,Winston F.,Roeder R.G.,Kornberg R.D.
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Mol. Cell
14
553-557
2004
614255
Liu Y.,Kung C.,Fishburn J.,Ansari A.Z.,Shokat K.M.,Hahn S.
Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex.
Mol. Cell. Biol.
24
1721-1735
2004
614256
Green S.R.,Johnson A.D.
Promoter-dependent roles for the Srb10 cyclin-dependent kinase and the Hda1 deacetylase in Tup1-mediated repression in Saccharomyces cerevisiae.
Mol. Biol. Cell
15
4191-4202
2004
614257
Guglielmi B.,van Berkum N.L.,Klapholz B.,Bijma T.,Boube M.,Boschiero C.,Bourbon H.-M.,Holstege F.C.P.,Werner M.
A high resolution protein interaction map of the yeast Mediator complex.
Nucleic Acids Res.
32
5379-5391
2004
614258
Hallberg M.,Polozkov G.V.,Hu G.-Z.,Beve J.,Gustafsson C.M.,Ronne H.,Bjoerklund S.
Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-micrometer plasmid.
Proc. Natl. Acad. Sci. U.S.A.
101
3370-3375
2004
614259
Nair D.,Kim Y.,Myers L.C.
Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts.
J. Biol. Chem.
280
33739-33748
2005
614260
van de Peppel J.,Kettelarij N.,van Bakel H.,Kockelkorn T.T.J.P.,van Leenen D.,Holstege F.C.P.
Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.
Mol. Cell
19
511-522
2005
614261
Larschan E.,Winston F.
The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.
Mol. Cell. Biol.
25
114-123
2005
614262
Ansari A.Z.,Ogirala A.,Ptashne M.
Transcriptional activating regions target attached substrates to a cyclin-dependent kinase.
Proc. Natl. Acad. Sci. U.S.A.
102
2346-2349
2005
614263
Andrau J.-C.,van de Pasch L.,Lijnzaad P.,Bijma T.,Koerkamp M.G.,van de Peppel J.,Werner M.,Holstege F.C.P.
Genome-wide location of the coactivator mediator: binding without activation and transient Cdk8 interaction on DNA.
Mol. Cell
22
179-192
2006