Sequence of ROCK1_HUMAN
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MSTGDSFETR FEKMDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK NIDNFLSRYK
60 DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF
120 FWEERDIMAF ANSPWVVQLF YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA
180 EVVLALDAIH SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY
240 ISPEVLKSQG GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP
300 DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD TVAPVVPDLS
360 SDIDTSNFDD LEEDKGEEET FPIPKAFVGN QLPFVGFTYY SNRRYLSSAN PNDNRTSSNA
420 DKSLQESLQK TIYKLEEQLH NEMQLKDEME QKCRTSNIKL DKIMKELDEE GNQRRNLEST
480 VSQIEKEKML LQHRINEYQR KAEQENEKRR NVENEVSTLK DQLEDLKKVS QNSQLANEKL
540 SQLQKQLEEA NDLLRTESDT AVRLRKSHTE MSKSISQLES LNRELQERNR ILENSKSQTD
600 KDYYQLQAIL EAERRDRGHD SEMIGDLQAR ITSLQEEVKH LKHNLEKVEG ERKEAQDMLN
660 HSEKEKNNLE IDLNYKLKSL QQRLEQEVNE HKVTKARLTD KHQSIEEAKS VAMCEMEKKL
720 KEEREAREKA ENRVVQIEKQ CSMLDVDLKQ SQQKLEHLTG NKERMEDEVK NLTLQLEQES
780 NKRLLLQNEL KTQAFEADNL KGLEKQMKQE INTLLEAKRL LEFELAQLTK QYRGNEGQMR
840 ELQDQLEAEQ YFSTLYKTQV KELKEEIEEK NRENLKKIQE LQNEKETLAT QLDLAETKAE
900 SEQLARGLLE EQYFELTQES KKAASRNRQE ITDKDHTVSR LEEANSMLTK DIEILRRENE
960 ELTEKMKKAE EEYKLEKEEE ISNLKAAFEK NINTERTLKT QAVNKLAEIM NRKDFKIDRK
1020 KANTQDLRKK EKENRKLQLE LNQEREKFNQ MVVKHQKELN DMQAQLVEEC AHRNELQMQL
1080 ASKESDIEQL RAKLLDLSDS TSVASFPSAD ETDGNLPESR IEGWLSVPNR GNIKRYGWKK
1140 QYVVVSSKKI LFYNDEQDKE QSNPSMVLDI DKLFHVRPVT QGDVYRAETE EIPKIFQILY
1200 ANEGECRKDV EMEPVQQAEK TNFQNHKGHE FIPTLYHFPA NCDACAKPLW HVFKPPPALE
1260 CRRCHVKCHR DHLDKKEDLI CPCKVSYDVT SARDMLLLAC SQDEQKKWVT HLVKKIPKNP
1320 PSGFVRASPR TLSTRSTANQ SFRKVVKNTS GKTS
Download this sequence
Download all sequences for 2.7.11.1
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
602787
Ishizaki T.,Maekawa M.,Fujisawa K.,Okawa K.,Iwamatsu A.,Fujita A.,Watanabe N.,Saito Y.,Kakizuka A.,Morii N.,Narumiya S.
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
EMBO J.
15
1885-1893
1996
602789
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
602792
Van Eyk J.E.,Arrell D.K.,Foster D.B.,Strauss J.D.,Heinonen T.Y.,Furmaniak-Kazmierczak E.,Cote G.P.,Mak A.S.
Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle.
J. Biol. Chem.
273
23433-23439
1998
602793
Scanlan M.J.,Gordan J.D.,Williamson B.,Stockert E.,Bander N.H.,Jongeneel C.V.,Gure A.O.,Jaeger D.,Jaeger E.,Knuth A.,Chen Y.-T.,Old L.J.
Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
Int. J. Cancer
83
456-464
1999
602794
Maekawa M.,Ishizaki T.,Boku S.,Watanabe N.,Fujita A.,Iwamatsu A.,Obinata T.,Ohashi K.,Mizuno K.,Narumiya S.
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Science
285
895-898
1999
602795
Ohashi K.,Nagata K.,Maekawa M.,Ishizaki T.,Narumiya S.,Mizuno K.
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.
J. Biol. Chem.
275
3577-3582
2000
602796
Sumi T.,Matsumoto K.,Nakamura T.
Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.
J. Biol. Chem.
276
670-676
2001
602797
Sebbagh M.,Renvoize C.,Hamelin J.,Riche N.,Bertoglio J.,Breard J.
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing.
Nat. Cell Biol.
3
346-352
2001
602798
Ward Y.,Yap S.-F.,Ravichandran V.,Matsumura F.,Ito M.,Spinelli B.,Kelly K.
The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway.
J. Cell Biol.
157
291-302
2002
602799
Riento K.,Guasch R.M.,Garg R.,Jin B.,Ridley A.J.
RhoE binds to ROCK I and inhibits downstream signaling.
Mol. Cell. Biol.
23
4219-4229
2003
602800
Riento K.,Ridley A.J.
Rocks: multifunctional kinases in cell behaviour.
Nat. Rev. Mol. Cell Biol.
4
446-456
2003
602801
Morita E.,Sandrin V.,Chung H.Y.,Morham S.G.,Gygi S.P.,Rodesch C.K.,Sundquist W.I.
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
EMBO J.
26
4215-4227
2007
602802
Hagerty L.,Weitzel D.H.,Chambers J.,Fortner C.N.,Brush M.H.,Loiselle D.,Hosoya H.,Haystead T.A.
ROCK1 phosphorylates and activates zipper-interacting protein kinase.
J. Biol. Chem.
282
4884-4893
2007
602803
Hannemann S.,Madrid R.,Stastna J.,Kitzing T.,Gasteier J.,Schoenichen A.,Bouchet J.,Jimenez A.,Geyer M.,Grosse R.,Benichou S.,Fackler O.T.
The diaphanous-related formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.
J. Biol. Chem.
283
27891-27903
2008
602804
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
602805
Shao J.,Welch W.J.,Diprospero N.A.,Diamond M.I.
Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.
Mol. Cell. Biol.
28
5196-5208
2008
602806
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
602807
Ongusaha P.P.,Qi H.H.,Raj L.,Kim Y.B.,Aaronson S.A.,Davis R.J.,Shi Y.,Liao J.K.,Lee S.W.
Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Sci. Signal.
1
0-0
2008
602808
Kroll J.,Epting D.,Kern K.,Dietz C.T.,Feng Y.,Hammes H.P.,Wieland T.,Augustin H.G.
Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis.
Am. J. Physiol.
296
0-0
2009
602809
Wang Y.,Zheng X.R.,Riddick N.,Bryden M.,Baur W.,Zhang X.,Surks H.K.
ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.
Circ. Res.
104
531-540
2009
602810
Lock F.E.,Hotchin N.A.
Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.
PLoS ONE
4
0-0
2009
602811
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
602812
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
602813
Ferretti R.,Palumbo V.,Di Savino A.,Velasco S.,Sbroggio M.,Sportoletti P.,Micale L.,Turco E.,Silengo L.,Palumbo G.,Hirsch E.,Teruya-Feldstein J.,Bonaccorsi S.,Pandolfi P.P.,Gatti M.,Tarone G.,Brancaccio M.
Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.
Dev. Cell
18
486-495
2010
602814
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
602815
Gabet A.S.,Coulon S.,Fricot A.,Vandekerckhove J.,Chang Y.,Ribeil J.A.,Lordier L.,Zermati Y.,Asnafi V.,Belaid Z.,Debili N.,Vainchenker W.,Varet B.,Hermine O.,Courtois G.
Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling.
Cell Death Differ.
18
678-689
2011
602816
Amano M.,Nakayama M.,Kaibuchi K.
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.
Cytoskeleton
67
545-554
2010
602817
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
602818
Schofield A.V.,Steel R.,Bernard O.
Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration.
J. Biol. Chem.
287
43620-43629
2012
602819
Mohan S.,Rizaldy R.,Das D.,Bauer R.J.,Heroux A.,Trakselis M.A.,Hildebrand J.D.,VanDemark A.P.
Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.
Mol. Biol. Cell
23
2131-2142
2012
602820
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
602821
Schofield A.V.,Gamell C.,Suryadinata R.,Sarcevic B.,Bernard O.
Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation.
J. Biol. Chem.
288
7907-7917
2013
602822
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
602823
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
602824
Dvorsky R.,Blumenstein L.,Vetter I.R.,Ahmadian M.R.
Structural insights into the interaction of ROCKI with the switch regions of RhoA.
J. Biol. Chem.
279
7098-7104
2004
602825
Jacobs M.,Hayakawa K.,Swenson L.,Bellon S.,Fleming M.,Taslimi P.,Doran J.
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
J. Biol. Chem.
281
260-268
2006
602826
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007