Sequence of LOXL2_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
protein-lysine 6-oxidase
Q9Y4K0
Homo sapiens
774
86725
Reaction
[protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MERPLCSHLC SCLAMLALLS PLSLAQYDSW PHYPEYFQQP APEYHQPQAP ANVAKIQLRL
 60 AGQKRKHSEG RVEVYYDGQW GTVCDDDFSI HAAHVVCREL GYVEAKSWTA SSSYGKGEGP
120 IWLDNLHCTG NEATLAACTS NGWGVTDCKH TEDVGVVCSD KRIPGFKFDN SLINQIENLN
180 IQVEDIRIRA ILSTYRKRTP VMEGYVEVKE GKTWKQICDK HWTAKNSRVV CGMFGFPGER
240 TYNTKVYKMF ASRRKQRYWP FSMDCTGTEA HISSCKLGPQ VSLDPMKNVT CENGLPAVVS
300 CVPGQVFSPD GPSRFRKAYK PEQPLVRLRG GAYIGEGRVE VLKNGEWGTV CDDKWDLVSA
360 SVVCRELGFG SAKEAVTGSR LGQGIGPIHL NEIQCTGNEK SIIDCKFNAE SQGCNHEEDA
420 GVRCNTPAMG LQKKLRLNGG RNPYEGRVEV LVERNGSLVW GMVCGQNWGI VEAMVVCRQL
480 GLGFASNAFQ ETWYWHGDVN SNKVVMSGVK CSGTELSLAH CRHDGEDVAC PQGGVQYGAG
540 VACSETAPDL VLNAEMVQQT TYLEDRPMFM LQCAMEENCL SASAAQTDPT TGYRRLLRFS
600 SQIHNNGQSD FRPKNGRHAW IWHDCHRHYH SMEVFTHYDL LNLNGTKVAE GHKASFCLED
660 TECEGDIQKN YECANFGDQG ITMGCWDMYR HDIDCQWVDI TDVPPGDYLF QVVINPNFEV
720 AESDYSNNIM KCRSRYDGHR IWMYNCHIGG SFSEETEKKF EHFSGLLNNQ LSPQ
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
56092
Saito H.,Papaconstantinou J.,Sato H.,Goldstein S.
Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence.
J. Biol. Chem.
272
8157-8160
1997
56093
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
56095
Nusbaum C.,Mikkelsen T.S.,Zody M.C.,Asakawa S.,Taudien S.,Garber M.,Kodira C.D.,Schueler M.G.,Shimizu A.,Whittaker C.A.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Yang X.,Allen N.R.,Anderson S.,Asakawa T.,Blechschmidt K.,Bloom T.,Borowsky M.L.,Butler J.,Cook A.,Corum B.,DeArellano K.,DeCaprio D.,Dooley K.T.,Dorris L. III,Engels R.,Gloeckner G.,Hafez N.,Hagopian D.S.,Hall J.L.,Ishikawa S.K.,Jaffe D.B.,Kamat A.,Kudoh J.,Lehmann R.,Lokitsang T.,Macdonald P.,Major J.E.,Matthews C.D.,Mauceli E.,Menzel U.,Mihalev A.H.,Minoshima S.,Murayama Y.,Naylor J.W.,Nicol R.,Nguyen C.,O'Leary S.B.,O'Neill K.,Parker S.C.J.,Polley A.,Raymond C.K.,Reichwald K.,Rodriguez J.,Sasaki T.,Schilhabel M.,Siddiqui R.,Smith C.L.,Sneddon T.P.,Talamas J.A.,Tenzin P.,Topham K.,Venkataraman V.,Wen G.,Yamazaki S.,Young S.K.,Zeng Q.,Zimmer A.R.,Rosenthal A.,Birren B.W.,Platzer M.,Shimizu N.,Lander E.S.
DNA sequence and analysis of human chromosome 8.
Nature
439
331-335
2006
56096
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
56097
Jourdan-Le Saux C.,Tronecker H.,Bogic L.,Bryant-Greenwood G.D.,Boyd C.D.,Csiszar K.
The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues.
J. Biol. Chem.
274
12939-12944
1999
56098
Peinado H.,Del Carmen Iglesias-de la Cruz M.,Olmeda D.,Csiszar K.,Fong K.S.,Vega S.,Nieto M.A.,Cano A.,Portillo F.
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.
EMBO J.
24
3446-3458
2005
56099
Schietke R.,Warnecke C.,Wacker I.,Schodel J.,Mole D.R.,Campean V.,Amann K.,Goppelt-Struebe M.,Behrens J.,Eckardt K.U.,Wiesener M.S.
The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1.
J. Biol. Chem.
285
6658-6669
2010
56100
Rodriguez H.M.,Vaysberg M.,Mikels A.,McCauley S.,Velayo A.C.,Garcia C.,Smith V.
Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor.
J. Biol. Chem.
285
20964-20974
2010
56101
Barry-Hamilton V.,Spangler R.,Marshall D.,McCauley S.,Rodriguez H.M.,Oyasu M.,Mikels A.,Vaysberg M.,Ghermazien H.,Wai C.,Garcia C.A.,Velayo A.C.,Jorgensen B.,Biermann D.,Tsai D.,Green J.,Zaffryar-Eilot S.,Holzer A.,Ogg S.,Thai D.,Neufeld G.,Van Vlasselaer P.,Smith V.
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment.
Nat. Med.
16
1009-1017
2010
56102
Bignon M.,Pichol-Thievend C.,Hardouin J.,Malbouyres M.,Brechot N.,Nasciutti L.,Barret A.,Teillon J.,Guillon E.,Etienne E.,Caron M.,Joubert-Caron R.,Monnot C.,Ruggiero F.,Muller L.,Germain S.
Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane.
Blood
118
3979-3989
2011
56103
Barker H.E.,Chang J.,Cox T.R.,Lang G.,Bird D.,Nicolau M.,Evans H.R.,Gartland A.,Erler J.T.
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.
Cancer Res.
71
1561-1572
2011
56104
Moreno-Bueno G.,Salvador F.,Martin A.,Floristan A.,Cuevas E.P.,Santos V.,Montes A.,Morales S.,Castilla M.A.,Rojo-Sebastian A.,Martinez A.,Hardisson D.,Csiszar K.,Portillo F.,Peinado H.,Palacios J.,Cano A.
Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.
EMBO Mol. Med.
3
528-544
2011
56105
Kim Y.M.,Kim E.C.,Kim Y.
The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.
Mol. Biol. Rep.
38
145-149
2011
56106
Li T.Y.,Xu L.Y.,Wu Z.Y.,Liao L.D.,Shen J.H.,Xu X.E.,Du Z.P.,Zhao Q.,Li E.M.
Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.
Hum. Pathol.
43
1068-1076
2012
56107
Lugassy J.,Zaffryar-Eilot S.,Soueid S.,Mordoviz A.,Smith V.,Kessler O.,Neufeld G.
The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation.
J. Biol. Chem.
287
3541-3549
2012
56108
Herranz N.,Dave N.,Millanes-Romero A.,Morey L.,Diaz V.M.,Lorenz-Fonfria V.,Gutierrez-Gallego R.,Jeronimo C.,Di Croce L.,Garcia de Herreros A.,Peiro S.
Lysyl oxidase-like 2 deaminates lysine 4 in histone H3.
Mol. Cell
46
369-376
2012
56109
Herranz N.,Dave N.,Millanes-Romero A.,Morey L.,Diaz V.M.,Lorenz-Fonfria V.,Gutierrez-Gallego R.,Jeronimo C.,Di Croce L.,Garcia de Herreros A.,Peiro S.
Mol. Cell
63
180-180
2016
56110
Xu L.,Go E.P.,Finney J.,Moon H.,Lantz M.,Rebecchi K.,Desaire H.,Mure M.
Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells.
J. Biol. Chem.
288
5357-5363
2013
56111
Millanes-Romero A.,Herranz N.,Perrera V.,Iturbide A.,Loubat-Casanovas J.,Gil J.,Jenuwein T.,Garcia de Herreros A.,Peiro S.
Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition.
Mol. Cell
52
746-757
2013
56112
Cuevas E.P.,Moreno-Bueno G.,Canesin G.,Santos V.,Portillo F.,Cano A.
LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.
Biol. Open
3
129-137
2014
56113
Iturbide A.,Pascual-Reguant L.,Fargas L.,Cebria J.P.,Alsina B.,Garcia de Herreros A.,Peiro S.
LOXL2 oxidizes methylated TAF10 and controls TFIID-dependent genes during neural progenitor differentiation.
Mol. Cell
58
755-766
2015
56114
Herranz N.,Dave N.,Millanes-Romero A.,Pascual-Reguant L.,Morey L.,Diaz V.M.,Lorenz-Fonfria V.,Gutierrez-Gallego R.,Jeronimo C.,Iturbide A.,Di Croce L.,Garcia de Herreros A.,Peiro S.
Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.
FEBS J.
283
4263-4273
2016
56115
Cuevas E.P.,Eraso P.,Mazon M.J.,Santos V.,Moreno-Bueno G.,Cano A.,Portillo F.
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.
Sci. Rep.
7
44988-44988
2017
56116
Zhang X.,Wang Q.,Wu J.,Wang J.,Shi Y.,Liu M.
Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state.
Proc. Natl. Acad. Sci. U.S.A.
115
3828-3833
2018