Sequence of ABCG2_MOUSE
EC Number:7.6.2.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2]
Other sequences found for EC No. 7.6.2.2
General information:
Sequence
0 MSSSNDHVLV PMSQRNNNGL PRTNSRAVRT LAEGDVLSFH HITYRVKVKS GFLVRKTVEK
60 EILSDINGIM KPGLNAILGP TGGGKSSLLD VLAARKDPKG LSGDVLINGA PQPAHFKCCS
120 GYVVQDDVVM GTLTVRENLQ FSAALRLPTT MKNHEKNERI NTIIKELGLE KVADSKVGTQ
180 FIRGISGGER KRTSIGMELI TDPSILFLDE PTTGLDSSTA NAVLLLLKRM SKQGRTIIFS
240 IHQPRYSIFK LFDSLTLLAS GKLVFHGPAQ KALEYFASAG YHCEPYNNPA DFFLDVINGD
300 SSAVMLNREE QDNEANKTEE PSKGEKPVIE NLSEFYINSA IYGETKAELD QLPGAQEKKG
360 TSAFKEPVYV TSFCHQLRWI ARRSFKNLLG NPQASVAQLI VTVILGLIIG AIYFDLKYDA
420 AGMQNRAGVL FFLTTNQCFS SVSAVELFVV EKKLFIHEYI SGYYRVSSYF FGKVMSDLLP
480 MRFLPSVIFT CVLYFMLGLK KTVDAFFIMM FTLIMVAYTA SSMALAIATG QSVVSVATLL
540 MTIAFVFMML FSGLLVNLRT IGPWLSWLQY FSIPRYGFTA LQYNEFLGQE FCPGFNVTDN
600 STCVNSYAIC TGNEYLINQG IELSPWGLWK NHVALACMII IFLTIAYLKL LFLKKYS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1273
Allen J.D.,Brinkhuis R.F.,Wijnholds J.,Schinkel A.H.
The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.
Cancer Res.
59
4237-4241
1999
1274
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1275
Allikmets R.,Schriml L.M.,Hutchinson A.,Romano-Spica V.,Dean M.
A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.
Cancer Res.
58
5337-5339
1998
1276
Jonker J.W.,Smit J.W.,Brinkhuis R.F.,Maliepaard M.,Beijnen J.H.,Schellens J.H.,Schinkel A.H.
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.
J. Natl. Cancer Inst.
92
1651-1656
2000
1277
Zhou S.,Schuetz J.D.,Bunting K.D.,Colapietro A.M.,Sampath J.,Morris J.J.,Lagutina I.,Grosveld G.C.,Osawa M.,Nakauchi H.,Sorrentino B.P.
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype.
Nat. Med.
7
1028-1034
2001
1278
Allen J.D.,van Loevezijn A.,Lakhai J.M.,van der Valk M.,van Tellingen O.,Reid G.,Schellens J.H.,Koomen G.J.,Schinkel A.H.
Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.
Mol. Cancer Ther.
1
417-425
2002
1279
Jonker J.W.,Buitelaar M.,Wagenaar E.,Van Der Valk M.A.,Scheffer G.L.,Scheper R.J.,Plosch T.,Kuipers F.,Elferink R.P.,Rosing H.,Beijnen J.H.,Schinkel A.H.
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Proc. Natl. Acad. Sci. U.S.A.
99
15649-15654
2002
1280
Krishnamurthy P.,Ross D.D.,Nakanishi T.,Bailey-Dell K.,Zhou S.,Mercer K.E.,Sarkadi B.,Sorrentino B.P.,Schuetz J.D.
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.
J. Biol. Chem.
279
24218-24225
2004
1281
van Herwaarden A.E.,Wagenaar E.,Merino G.,Jonker J.W.,Rosing H.,Beijnen J.H.,Schinkel A.H.
Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.
Mol. Cell. Biol.
27
1247-1253
2007
1282
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
1283
Takada T.,Yamamoto T.,Matsuo H.,Tan J.K.,Ooyama K.,Sakiyama M.,Miyata H.,Yamanashi Y.,Toyoda Y.,Higashino T.,Nakayama A.,Nakashima A.,Shinomiya N.,Ichida K.,Ooyama H.,Fujimori S.,Suzuki H.
Identification of ABCG2 as an exporter of uremic toxin indoxyl sulfate in mice and as a crucial factor influencing CKD progression.
Sci. Rep.
8
11147-11147
2018
