Sequence of NOS1_RAT
EC Number:1.14.13.39
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
2 L-arginine + 2 NADPH + 2 H+ + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 NADP+ + 2 H2O
Other sequences found for EC No. 1.14.13.39
General information:
Sequence
0 MEENTFGVQQ IQPNVISVRL FKRKVGGLGF LVKERVSKPP VIISDLIRGG AAEQSGLIQA
60 GDIILAVNDR PLVDLSYDSA LEVLRGIASE THVVLILRGP EGFTTHLETT FTGDGTPKTI
120 RVTQPLGPPT KAVDLSHQPS ASKDQSLAVD RVTGLGNGPQ HAQGHGQGAG SVSQANGVAI
180 DPTMKSTKAN LQDIGEHDEL LKEIEPVLSI LNSGSKATNR GGPAKAEMKD TGIQVDRDLD
240 GKSHKAPPLG GDNDRVFNDL WGKDNVPVIL NNPYSEKEQS PTSGKQSPTK NGSPSRCPRF
300 LKVKNWETDV VLTDTLHLKS TLETGCTEHI CMGSIMLPSQ HTRKPEDVRT KDQLFPLAKE
360 FLDQYYSSIK RFGSKAHMDR LEEVNKEIES TSTYQLKDTE LIYGAKHAWR NASRCVGRIQ
420 WSKLQVFDAR DCTTAHGMFN YICNHVKYAT NKGNLRSAIT IFPQRTDGKH DFRVWNSQLI
480 RYAGYKQPDG STLGDPANVQ FTEICIQQGW KAPRGRFDVL PLLLQANGND PELFQIPPEL
540 VLEVPIRHPK FDWFKDLGLK WYGLPAVSNM LLEIGGLEFS ACPFSGWYMG TEIGVRDYCD
600 NSRYNILEEV AKKMDLDMRK TSSLWKDQAL VEINIAVLYS FQSDKVTIVD HHSATESFIK
660 HMENEYRCRG GCPADWVWIV PPMSGSITPV FHQEMLNYRL TPSFEYQPDP WNTHVWKGTN
720 GTPTKRRAIG FKKLAEAVKF SAKLMGQAMA KRVKATILYA TETGKSQAYA KTLCEIFKHA
780 FDAKAMSMEE YDIVHLEHEA LVLVVTSTFG NGDPPENGEK FGCALMEMRH PNSVQEERKS
840 YKVRFNSVSS YSDSRKSSGD GPDLRDNFES TGPLANVRFS VFGLGSRAYP HFCAFGHAVD
900 TLLEELGGER ILKMREGDEL CGQEEAFRTW AKKVFKAACD VFCVGDDVNI EKPNNSLISN
960 DRSWKRNKFR LTYVAEAPDL TQGLSNVHKK RVSAARLLSR QNLQSPKFSR STIFVRLHTN
1020 GNQELQYQPG DHLGVFPGNH EDLVNALIER LEDAPPANHV VKVEMLEERN TALGVISNWK
1080 DESRLPPCTI FQAFKYYLDI TTPPTPLQLQ QFASLATNEK EKQRLLVLSK GLQEYEEWKW
1140 GKNPTMVEVL EEFPSIQMPA TLLLTQLSLL QPRYYSISSS PDMYPDEVHL TVAIVSYHTR
1200 DGEGPVHHGV CSSWLNRIQA DDVVPCFVRG APSFHLPRNP QVPCILVGPG TGIAPFRSFW
1260 QQRQFDIQHK GMNPCPMVLV FGCRQSKIDH IYREETLQAK NKGVFRELYT AYSREPDRPK
1320 KYVQDVLQEQ LAESVYRALK EQGGHIYVCG DVTMAADVLK AIQRIMTQQG KLSEEDAGVF
1380 ISRLRDDNRY HEDIFGVTLR TYEVTNRLRS ESIAFIEESK KDADEVFSS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
577578
Bredt D.S.,Hwang P.M.,Glatt C.L.,Lowenstein C.,Reed R.R.,Snyder S.H.
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
Nature
351
714-718
1991
577579
Magee T.,Fuentes A.M.,Garban H.,Rajavashisth T.,Marquez D.,Rodriguez J.A.,Rajfer J.,Gonzalez-Cadavid N.F.
Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract.
Biochem. Biophys. Res. Commun.
226
145-151
1996
577580
Seo H.G.,Tatsumi H.,Fujii J.,Nishikawa A.,Suzuki K.,Kangawa K.,Taniguchi N.
Nitric oxide synthase from rat colorectum: purification, peptide sequencing, partial PCR cloning, and immunohistochemistry.
J. Biochem.
115
602-607
1994
577581
Uvarov V.Y.,Lyashenko A.A.
The identification of the pterin-binding domain in the nitric oxide synthase's sequence.
Biochem. Biophys. Res. Commun.
206
736-741
1995
577582
Sato Y.,Sagami I.,Matsui T.,Shimizu T.
Unusual role of Tyr588 of neuronal nitric oxide synthase in controlling substrate specificity and electron transfer.
Biochem. Biophys. Res. Commun.
281
621-626
2001
577583
Fang M.,Jaffrey S.R.,Sawa A.,Ye K.,Luo X.,Snyder S.H.
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.
Neuron
28
183-193
2000
577584
Jaffrey S.R.,Benfenati F.,Snowman A.M.,Czernik A.J.,Snyder S.H.
Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON.
Proc. Natl. Acad. Sci. U.S.A.
99
3199-3204
2002
577585
Saitoh F.,Tian Q.B.,Okano A.,Sakagami H.,Kondo H.,Suzuki T.
NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity.
J. Biol. Chem.
279
29461-29468
2004
577586
Peng H.M.,Morishima Y.,Jenkins G.J.,Dunbar A.Y.,Lau M.,Patterson C.,Pratt W.B.,Osawa Y.
Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
J. Biol. Chem.
279
52970-52977
2004
577587
Dreyer J.,Schleicher M.,Tappe A.,Schilling K.,Kuner T.,Kusumawidijaja G.,Mueller-Esterl W.,Oess S.,Kuner R.
Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity.
J. Neurosci.
24
10454-10465
2004
577588
Lemaire J.F.,McPherson P.S.
Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif.
FEBS Lett.
580
6948-6954
2006
577589
Lundby A.,Secher A.,Lage K.,Nordsborg N.B.,Dmytriyev A.,Lundby C.,Olsen J.V.
Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
Nat. Commun.
3
876-876
2012
577590
Akama K.T.,Thompson L.I.,Milner T.A.,McEwen B.S.
Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines.
J. Biol. Chem.
288
6438-6450
2013
577591
Hillier B.J.,Christopherson K.S.,Prehoda K.E.,Bredt D.S.,Lim W.A.
Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex.
Science
284
812-815
1999
577592
Zhang J.,Martasek P.,Paschke R.,Shea T.,Masters B.S.S.,Kim J.-J.P.
Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with nadph-cytochrome p450 oxidoreductase.
J. Biol. Chem.
276
37506-37513
2001
