Sequence of NUDT5_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
ADP-ribose diphosphatase
Q9UKK9
Homo sapiens
219
24328
Reaction
ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD
 60 GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK
120 GDIAECSPAV CMDPGLSNCT IHIVTVTING DDAENARPKP KPGDGEFVEV ISLPKNDLLQ
180 RLDALVAEEH LTVDARVYSY ALALKHANAK PFEVPFLKF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
569992
Gasmi L.,Cartwright J.L.,McLennan A.G.
Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif.
Biochem. J.
344
331-337
1999
569993
Yang H.,Slupska M.M.,Wei Y.-F.,Tai J.H.,Luther W.M.,Xia Y.-R.,Shih D.M.,Chiang J.-H.,Baikalov C.,Fitz-Gibbon S.,Phan I.T.,Conrad A.,Miller J.H.
Cloning and characterization of a new member of the Nudix hydrolases from human and mouse.
J. Biol. Chem.
275
8844-8853
2000
569994
Zhang Q.-H.,Ye M.,Wu X.-Y.,Ren S.-X.,Zhao M.,Zhao C.-J.,Fu G.,Shen Y.,Fan H.-Y.,Lu G.,Zhong M.,Xu X.-R.,Han Z.-G.,Zhang J.-W.,Tao J.,Huang Q.-H.,Zhou J.,Hu G.-X.,Gu J.,Chen S.-J.,Chen Z.
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
Genome Res.
10
1546-1560
2000
569996
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
569998
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
569999
Rush J.,Moritz A.,Lee K.A.,Guo A.,Goss V.L.,Spek E.J.,Zhang H.,Zha X.-M.,Polakiewicz R.D.,Comb M.J.
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Nat. Biotechnol.
23
94-101
2005
570000
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
570001
Kamiya H.,Hori M.,Arimori T.,Sekiguchi M.,Yamagata Y.,Harashima H.
NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity.
DNA Repair
8
1250-1254
2009
570002
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
570003
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
570004
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
570005
Ito R.,Sekiguchi M.,Setoyama D.,Nakatsu Y.,Yamagata Y.,Hayakawa H.
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein.
J. Biochem.
149
731-738
2011
570006
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
570007
Rosenow A.,Noben J.P.,Jocken J.,Kallendrusch S.,Fischer-Posovszky P.,Mariman E.C.,Renes J.
Resveratrol-induced changes of the human adipocyte secretion profile.
J. Proteome Res.
11
4733-4743
2012
570008
Bienvenut W.V.,Sumpton D.,Martinez A.,Lilla S.,Espagne C.,Meinnel T.,Giglione C.
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
Mol. Cell. Proteomics
11
0-0
2012
570009
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
570010
Wright R.H.,Lioutas A.,Le Dily F.,Soronellas D.,Pohl A.,Bonet J.,Nacht A.S.,Samino S.,Font-Mateu J.,Vicent G.P.,Wierer M.,Trabado M.A.,Schelhorn C.,Carolis C.,Macias M.J.,Yanes O.,Oliva B.,Beato M.
ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.
Science
352
1221-1225
2016
570011
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
570012
Zha M.,Zhong C.,Peng Y.,Hu H.,Ding J.
Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity.
J. Mol. Biol.
364
1021-1033
2006
570013
Zha M.,Guo Q.,Zhang Y.,Yu B.,Ou Y.,Zhong C.,Ding J.
Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.
J. Mol. Biol.
379
568-578
2008
570014
Arimori T.,Tamaoki H.,Nakamura T.,Kamiya H.,Ikemizu S.,Takagi Y.,Ishibashi T.,Harashima H.,Sekiguchi M.,Yamagata Y.
Diverse substrate recognition and hydrolysis mechanisms of human NUDT5.
Nucleic Acids Res.
39
8972-8983
2011