Sequence of PNMT_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phenylethanolamine N-methyltransferase
P11086
Homo sapiens
282
30855
Reaction
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP NGVGPWKLRC
 60 LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT DFLEVNRQEL GRWLQEEPGA
120 FNWSMYSQHA CLIEGKGECW QDKERQLRAR VKRVLPIDVH QPQPLGAGSP APLPADALVS
180 AFCLEAVSPD LASFQRALDH ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR
240 EALVRSGYKV RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
567516
Kaneda N.,Ichinose H.,Kobayashi K.,Oka K.,Kishi F.,Nakazawa A.,Kurosawa Y.,Fujita K.,Nagatsu T.
Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine N-methyltransferase, the enzyme for epinephrine biosynthesis.
J. Biol. Chem.
263
7672-7677
1988
567518
Baetge E.E.,Behringer R.R.,Messing A.,Brinster R.L.,Palmiter R.D.
Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina.
Proc. Natl. Acad. Sci. U.S.A.
85
3648-3652
1988
567519
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
567520
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
567521
Martin J.L.,Begun J.,McLeish M.J.,Caine J.M.,Grunewald G.L.
Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.
Structure
9
977-985
2001
567522
Gee C.L.,Tyndall J.D.A.,Grunewald G.L.,Wu Q.,McLeish M.J.,Martin J.L.
Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis.
Biochemistry
44
16875-16885
2005
567523
Grunewald G.L.,Seim M.R.,Regier R.C.,Martin J.L.,Gee C.L.,Drinkwater N.,Criscione K.R.
Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
J. Med. Chem.
49
5424-5433
2006
567524
Gee C.L.,Drinkwater N.,Tyndall J.D.A.,Grunewald G.L.,Wu Q.,McLeish M.J.,Martin J.L.
Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.
J. Med. Chem.
50
4845-4853
2007
567525
Ji Y.,Salavaggione O.E.,Wang L.,Adjei A.A.,Eckloff B.,Wieben E.D.,Weinshilboum R.M.
Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics.
J. Neurochem.
95
1766-1776
2005