Sequence of MK15_HUMAN
EC Number:2.7.11.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.24
General information:
Sequence
0 MCTVVDPRIV RRYLLRRQLG QGAYGIVWKA VDRRTGEVVA IKKIFDAFRD KTDAQRTFRE
60 ITLLQEFGDH PNIISLLDVI RAENDRDIYL VFEFMDTDLN AVIRKGGLLQ DVHVRSIFYQ
120 LLRATRFLHS GHVVHRDQKP SNVLLDANCT VKLCDFGLAR SLGDLPEGPE DQAVTEYVAT
180 RWYRAPEVLL SSHRYTLGVD MWSLGCILGE MLRGRPLFPG TSTLHQLELI LETIPPPSEE
240 DLLALGSGCR ASVLHQLGSR PRQTLDALLP PDTSPEALDL LRRLLVFAPD KRLSATQALQ
300 HPYVQRFHCP SDEWAREADV RPRAHEGVQL SVPEYRSRVY QMILECGGSS GTSREKGPEG
360 VSPSQAHLHK PRADPQLPSR TPVQGPRPRP QSSPGHDPAE HESPRAAKNV PRQNSAPLLQ
420 TALLGNGERP PGAKEAPPLT LSLVKPSGRG AAPSLTSQAA AQVANQALIR GDWNRGGGVR
480 VASVQQVPPR LPPEARPGRR MFSTSALQGA QGGARALLGG YSQAYGTVCH SALGHLPLLE
540 GHHV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
570210
Abe M.K.,Saelzler M.P.,Espinosa R. III,Kahle K.T.,Hershenson M.B.,Le Beau M.M.,Rosner M.R.
ERK8, a new member of the mitogen-activated protein kinase family.
J. Biol. Chem.
277
16733-16743
2002
570211
Iavarone C.,Acunzo M.,Carlomagno F.,Catania A.,Melillo R.M.,Carlomagno S.M.,Santoro M.,Chiariello M.
Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.
J. Biol. Chem.
281
10567-10576
2006
570212
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
570213
Saelzler M.P.,Spackman C.C.,Liu Y.,Martinez L.C.,Harris J.P.,Abe M.K.
ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.
J. Biol. Chem.
281
16821-16832
2006
570214
Klevernic I.V.,Stafford M.J.,Morrice N.,Peggie M.,Morton S.,Cohen P.
Characterization of the reversible phosphorylation and activation of ERK8.
Biochem. J.
394
365-373
2006
570215
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
570216
Klevernic I.V.,Martin N.M.,Cohen P.
Regulation of the activity and expression of ERK8 by DNA damage.
FEBS Lett.
583
680-684
2009
570217
Erster O.,Seger R.,Liscovitch M.
Ligand interaction scan (LIScan) in the study of ERK8.
Biochem. Biophys. Res. Commun.
399
37-41
2010
570218
Groehler A.L.,Lannigan D.A.
A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.
J. Cell Biol.
190
575-586
2010
570219
Zacharogianni M.,Kondylis V.,Tang Y.,Farhan H.,Xanthakis D.,Fuchs F.,Boutros M.,Rabouille C.
ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association.
EMBO J.
30
3684-3700
2011
570220
Rossi M.,Colecchia D.,Iavarone C.,Strambi A.,Piccioni F.,Verrotti di Pianella A.,Chiariello M.
Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor alpha (ERRalpha) cellular localization and inhibits its transcriptional activity.
J. Biol. Chem.
286
8507-8522
2011
570221
Colecchia D.,Strambi A.,Sanzone S.,Iavarone C.,Rossi M.,Dall'Armi C.,Piccioni F.,Verrotti di Pianella A.,Chiariello M.
MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.
Autophagy
8
1724-1740
2012
570222
Chia J.,Tham K.M.,Gill D.J.,Bard-Chapeau E.A.,Bard F.A.
ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration.
Elife
3
0-0
2014
570223
Guo A.,Gu H.,Zhou J.,Mulhern D.,Wang Y.,Lee K.A.,Yang V.,Aguiar M.,Kornhauser J.,Jia X.,Ren J.,Beausoleil S.A.,Silva J.C.,Vemulapalli V.,Bedford M.T.,Comb M.J.
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
Mol. Cell. Proteomics
13
372-387
2014
570224
Liwak-Muir U.,Dobson C.C.,Naing T.,Wylie Q.,Chehade L.,Baird S.D.,Chakraborty P.K.,Holcik M.
ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.
Oncotarget
7
1439-1450
2016
570225
Kazatskaya A.,Kuhns S.,Lambacher N.J.,Kennedy J.E.,Brear A.G.,McManus G.J.,Sengupta P.,Blacque O.E.
Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.
Genetics
207
1423-1440
2017
570226
Bermingham D.P.,Hardaway J.A.,Refai O.,Marks C.R.,Snider S.L.,Sturgeon S.M.,Spencer W.C.,Colbran R.J.,Miller D.M. III,Blakely R.D.
The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism.
J. Neurosci.
37
9288-9304
2017
