Sequence of DCK_HUMAN

deoxycytidine kinase

P27707

260

30519

482862

Chottiner E.G.,Shewach D.S.,Datta N.S.,Ashcraft E.,Gribbin D.,Ginsburg D.,Fox I.H.,Mitchell B.S.

Cloning and expression of human deoxycytidine kinase cDNA.

Proc. Natl. Acad. Sci. U.S.A.

88

1531-1535

1991

482863

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

482867

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

482868

Eriksson S.,Cederlund E.,Bergman T.,Joernvall H.,Bohman C.

Characterization of human deoxycytidine kinase. Correlation with cDNA sequences.

FEBS Lett.

280

363-366

1991

482869

Johansson M.,Brismar S.,Karlsson A.

Human deoxycytidine kinase is located in the cell nucleus.

Proc. Natl. Acad. Sci. U.S.A.

94

11941-11945

1997

482870

Matsuoka S.,Ballif B.A.,Smogorzewska A.,McDonald E.R. III,Hurov K.E.,Luo J.,Bakalarski C.E.,Zhao Z.,Solimini N.,Lerenthal Y.,Shiloh Y.,Gygi S.P.,Elledge S.J.

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

Science

316

1160-1166

2007

482871

Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

Mol. Cell

31

438-448

2008

482872

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

482873

Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.

Large-scale proteomics analysis of the human kinome.

Mol. Cell. Proteomics

8

1751-1764

2009

482874

Smal C.,Vertommen D.,Amsailale R.,Arts A.,Degand H.,Morsomme P.,Rider M.H.,Neste E.V.,Bontemps F.

Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity.

Arch. Biochem. Biophys.

502

44-52

2010

482875

Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal.

3

RA3-RA3

2010

482876

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

482877

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

482878

Sabini E.,Ort S.,Monnerjahn C.,Konrad M.,Lavie A.

Structure of human dCK suggests strategies to improve anticancer and antiviral therapy.

Nat. Struct. Biol.

10

513-519

2003

482879

Zhang Y.,Secrist J.A. III,Ealick S.E.

The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.

Acta Crystallogr. D

62

133-139

2006

482880

Sabini E.,Hazra S.,Konrad M.,Lavie A.

Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides.

J. Med. Chem.

50

3004-3014

2007

482881

Sabini E.,Hazra S.,Ort S.,Konrad M.,Lavie A.

Structural basis for substrate promiscuity of dCK.

J. Mol. Biol.

378

607-621

2008

482882

Hazra S.,Sabini E.,Ort S.,Konrad M.,Lavie A.

Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.

Biochemistry

48

1256-1263

2009

482883

Jessop T.C.,Tarver J.E.,Carlsen M.,Xu A.,Healy J.P.,Heim-Riether A.,Fu Q.,Taylor J.A.,Augeri D.J.,Shen M.,Stouch T.R.,Swanson R.V.,Tari L.W.,Hunter M.,Hoffman I.,Keyes P.E.,Yu X.C.,Miranda M.,Liu Q.,Swaffield J.C.,David Kimball S.,Nouraldeen A.,Wilson A.G.,Foushee A.M.,Jhaver K.,Finch R.,Anderson S.,Oravecz T.,Carson K.G.

Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.

Bioorg. Med. Chem. Lett.

19

6784-6787

2009

482884

Hazra S.,Ort S.,Konrad M.,Lavie A.

Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues.

Biochemistry

49

6784-6790

2010

482885

Hazra S.,Konrad M.,Lavie A.

The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues.

J. Med. Chem.

53

5792-5800

2010