Sequence of FURIN_RAT
EC Number:3.4.21.75
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors
General information:
Sequence
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>P23377|Furin|EC 3.4.21.75|Rattus norvegicus|Swiss-Prot
MELRPWLLWVVAAAGALVLLAAEARGQKIFTNTWAVHISGGPAVADSVARKHGFHNLGQI
FGDYYHFWHRAVTKRSLSPHRPRHSRLQRVPQVKWLEQQVAKQRAKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLEVRKTVTACLGEPNH
ISRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASEGLSAPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQRCPPGFTPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCL
SCPSHASLDPVEQTCSRQSQSSRESRPQQPPPALRPEVEVEPRLRAGLASHLPEVLAGLS
CLIIALIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGR
GERTAFIKDQSAL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
465914
Misumi Y.,Sohoda M.,Ikehara Y.
Sequence of the cDNA encoding rat furin, a possible propeptide-processing endoprotease.
Nucleic Acids Res.
18
6719-6719
1990
465915
Sawada Y.,Suda M.,Yokoyama H.,Kanda T.,Sakamaki T.,Tanaka S.,Nagai R.,Abe S.,Takeuchi T.
Stretch-induced hypertrophic growth of cardiocytes and processing of brain-type natriuretic peptide are controlled by proprotein-processing endoprotease furin.
J. Biol. Chem.
272
20545-20554
1997
465916
Wan L.,Molloy S.S.,Thomas L.,Liu G.,Xiang Y.,Rybak S.L.,Thomas G.
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization.
Cell
94
205-216
1998
