Sequence of FURIN_RAT
EC Number:3.4.21.75
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors
General information:
Sequence
0 MELRPWLLWV VAAAGALVLL AAEARGQKIF TNTWAVHISG GPAVADSVAR KHGFHNLGQI
60 FGDYYHFWHR AVTKRSLSPH RPRHSRLQRV PQVKWLEQQV AKQRAKRDVY QEPTDPKFPQ
120 QWYLSGVTQR DLNVKEAWAQ GFTGRGIVVS ILDDGIEKNH PDLAGNYDPG ASFDVNDQDP
180 DPQPRYTQMN DNRHGTRCAG EVAAVANNGV CGVGVAYNAR IGGVRMLDGE VTDAVEARSL
240 GLNPNHIHIY SASWGPEDDG KTVDGPARLA EEAFFRGVSQ GRGGLGSIFV WASGNGGREH
300 DSCNCDGYTN SIYTLSISSA TQFGNVPWYS EACSSTLATT YSSGNQNEKQ IVTTDLRQKC
360 TESHTGTSAS APLAAGIIAL TLEANKNLTW RDMQHLVVQT SKPAHLNAND WATNGVGRKV
420 SHSYGYGLLD AGAMVALAQN WTTVAPQRKC IIEILAEPKD IGKRLEVRKT VTACLGEPNH
480 ISRLEHVQAR LTLSYNRRGD LAIHLISPMG TRSTLLAARP HDYSADGFND WAFMTTHSWD
540 EDPSGEWVLE IENTSEANNY GTLTKFTLVL YGTASEGLSA PPESSGCKTL TSSQACVVCE
600 EGFSLHQKSC VQRCPPGFTP QVLDTHYSTE NDVEIIRASV CTPCHASCAT CQGPAPTDCL
660 SCPSHASLDP VEQTCSRQSQ SSRESRPQQP PPALRPEVEV EPRLRAGLAS HLPEVLAGLS
720 CLIIALIFGI VFLFLHRCSG FSFRGVKVYT MDRGLISYKG LPPEAWQEEC PSDSEEDEGR
780 GERTAFIKDQ SAL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
465914
Misumi Y.,Sohoda M.,Ikehara Y.
Sequence of the cDNA encoding rat furin, a possible propeptide-processing endoprotease.
Nucleic Acids Res.
18
6719-6719
1990
465915
Sawada Y.,Suda M.,Yokoyama H.,Kanda T.,Sakamaki T.,Tanaka S.,Nagai R.,Abe S.,Takeuchi T.
Stretch-induced hypertrophic growth of cardiocytes and processing of brain-type natriuretic peptide are controlled by proprotein-processing endoprotease furin.
J. Biol. Chem.
272
20545-20554
1997
465916
Wan L.,Molloy S.S.,Thomas L.,Liu G.,Xiang Y.,Rybak S.L.,Thomas G.
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization.
Cell
94
205-216
1998
