Sequence of AMPL_YEAST
EC Number:3.4.11.22
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
General information:
Sequence
0 MEEQREILEQ LKKTLQMLTV EPSKNNQIAN EEKEKKENEN SWCILEHNYE DIAQEFIDFI
60 YKNPTTYHVV SFFAELLDKH NFKYLSEKSN WQDSIGEDGG KFYTIRNGTN LSAFILGKNW
120 RAEKGVGVIG SHVDALTVKL KPVSFKDTAE GYGRIAVAPY GGTLNELWLD RDLGIGGRLL
180 YKKKGTNEIK SALVDSTPLP VCRIPSLAPH FGKPAEGPFD KEDQTIPVIG FPTPDEEGNE
240 PPTDDEKKSP LFGKHCIHLL RYVAKLAGVE VSELIQMDLD LFDVQKGTIG GIGKHFLFAP
300 RLDDRLCSFA AMIALICYAK DVNTEESDLF STVTLYDNEE IGSLTRQGAK GGLLESVVER
360 SSSAFTKKPV DLHTVWANSI ILSADVNHLY NPNFPEVYLK NHFPVPNVGI TLSLDPNGHM
420 ATDVVGTALV EELARRNGDK VQYFQIKNNS RSGGTIGPSL ASQTGARTID LGIAQLSMHS
480 IRAATGSKDV GLGVKFFNGF FKHWRSVYDE FGEL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
430818
Cueva R.,Garcia-Alvarez N.,Suarez-Rendueles P.
Yeast vacuolar aminopeptidase yscI. Isolation and regulation of the APE1 (LAP4) structural gene.
FEBS Lett.
259
125-129
1989
430819
Chang Y.-H.,Smith J.A.
Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae.
J. Biol. Chem.
264
6979-6983
1989
430820
Cheret G.,Pallier C.,Valens M.,Daignan-Fornier B.,Fukuhara H.,Bolotin-Fukuhara M.,Sor F.
The DNA sequence analysis of the HAP4-LAP4 region on chromosome XI of Saccharomyces cerevisiae suggests the presence of a second aspartate aminotransferase gene in yeast.
Yeast
9
1259-1265
1993
430821
Dujon B.,Alexandraki D.,Andre B.,Ansorge W.,Baladron V.,Ballesta J.P.G.,Banrevi A.,Bolle P.-A.,Bolotin-Fukuhara M.,Bossier P.,Bou G.,Boyer J.,Buitrago M.J.,Cheret G.,Colleaux L.,Daignan-Fornier B.,del Rey F.,Dion C.,Domdey H.,Duesterhoeft A.,Duesterhus S.,Entian K.-D.,Erfle H.,Esteban P.F.,Feldmann H.,Fernandes L.,Fobo G.M.,Fritz C.,Fukuhara H.,Gabel C.,Gaillon L.,Garcia-Cantalejo J.M.,Garcia-Ramirez J.J.,Gent M.E.,Ghazvini M.,Goffeau A.,Gonzalez A.,Grothues D.,Guerreiro P.,Hegemann J.H.,Hewitt N.,Hilger F.,Hollenberg C.P.,Horaitis O.,Indge K.J.,Jacquier A.,James C.M.,Jauniaux J.-C.,Jimenez A.,Keuchel H.,Kirchrath L.,Kleine K.,Koetter P.,Legrain P.,Liebl S.,Louis E.J.,Maia e Silva A.,Marck C.,Monnier A.-L.,Moestl D.,Mueller S.,Obermaier B.,Oliver S.G.,Pallier C.,Pascolo S.,Pfeiffer F.,Philippsen P.,Planta R.J.,Pohl F.M.,Pohl T.M.,Poehlmann R.,Portetelle D.,Purnelle B.,Puzos V.,Ramezani Rad M.,Rasmussen S.W.,Remacha M.A.,Revuelta J.L.,Richard G.-F.,Rieger M.,Rodrigues-Pousada C.,Rose M.,Rupp T.,Santos M.A.,Schwager C.,Sensen C.,Skala J.,Soares H.,Sor F.,Stegemann J.,Tettelin H.,Thierry A.,Tzermia M.,Urrestarazu L.A.,van Dyck L.,van Vliet-Reedijk J.C.,Valens M.,Vandenbol M.,Vilela C.,Vissers S.,von Wettstein D.,Voss H.,Wiemann S.,Xu G.,Zimmermann J.,Haasemann M.,Becker I.,Mewes H.-W.
Complete DNA sequence of yeast chromosome XI.
Nature
369
371-378
1994
430822
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
430824
Matile P.,Wiemken A.,Guyer W.
A lysosomal aminopeptidase isozyme in differentiating yeast cells and protoplasts.
Planta
96
43-53
1971
430825
Metz G.,Roehm K.H.
Yeast aminopeptidase I. Chemical composition and catalytic properties.
Biochim. Biophys. Acta
429
933-949
1976
430826
Frey J.,Roehm K.H.
Subcellular localization and levels of aminopeptidases and dipeptidase in Saccharomyces cerevisiae.
Biochim. Biophys. Acta
527
31-41
1978
430827
Trumbly R.J.,Bradley G.
Isolation and characterization of aminopeptidase mutants of Saccharomyces cerevisiae.
J. Bacteriol.
156
36-48
1983
430828
Roehm K.H.
Chloride as allosteric effector of yeast aminopeptidase I.
Arch. Biochem. Biophys.
239
216-225
1985
430830
Achstetter T.,Wolf D.H.
Proteinases, proteolysis and biological control in the yeast Saccharomyces cerevisiae.
Yeast
1
139-157
1985
430831
Klionsky D.J.,Cueva R.,Yaver D.S.
Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway.
J. Cell Biol.
119
287-299
1992
430832
Segui-Real B.,Martinez M.,Sandoval I.V.
Yeast aminopeptidase I is post-translationally sorted from the cytosol to the vacuole by a mechanism mediated by its bipartite N-terminal extension.
EMBO J.
14
5476-5484
1995
430833
Oda M.N.,Scott S.V.,Hefner-Gravink A.,Caffarelli A.D.,Klionsky D.J.
Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.
J. Cell Biol.
132
999-1010
1996
430834
Scott S.V.,Hefner-Gravink A.,Morano K.A.,Noda T.,Ohsumi Y.,Klionsky D.J.
Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.
Proc. Natl. Acad. Sci. U.S.A.
93
12304-12308
1996
430835
Kim J.,Scott S.V.,Oda M.N.,Klionsky D.J.
Transport of a large oligomeric protein by the cytoplasm to vacuole protein targeting pathway.
J. Cell Biol.
137
609-618
1997
430836
Scott S.V.,Baba M.,Ohsumi Y.,Klionsky D.J.
Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism.
J. Cell Biol.
138
37-44
1997
430837
Baba M.,Osumi M.,Scott S.V.,Klionsky D.J.,Ohsumi Y.
Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome.
J. Cell Biol.
139
1687-1695
1997
430838
Andrei-Selmer C.,Knuppel A.,Satyanarayana C.,Heese C.,Schu P.V.
A new class of mutants deficient in dodecamerization of aminopeptidase 1 and vacuolar transport.
J. Biol. Chem.
276
11606-11614
2001
430839
Leber R.,Silles E.,Sandoval I.V.,Mazon M.J.
Yol082p, a novel CVT protein involved in the selective targeting of aminopeptidase I to the yeast vacuole.
J. Biol. Chem.
276
29210-29217
2001
430840
Scott S.V.,Guan J.,Hutchins M.U.,Kim J.,Klionsky D.J.
Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway.
Mol. Cell
7
1131-1141
2001
430841
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
430842
Shintani T.,Klionsky D.J.
Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway.
J. Biol. Chem.
279
29889-29894
2004
430843
Adachi W.,Suzuki N.N.,Fujioka Y.,Suzuki K.,Ohsumi Y.,Inagaki F.
Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway.
Acta Crystallogr. F
63
200-203
2007
430845
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
430846
Morales Quinones M.,Winston J.T.,Stromhaug P.E.
Propeptide of aminopeptidase 1 protein mediates aggregation and vesicle formation in cytoplasm-to-vacuole targeting pathway.
J. Biol. Chem.
287
10121-10133
2012
430847
Su M.Y.,Peng W.H.,Ho M.R.,Su S.C.,Chang Y.C.,Chen G.C.,Chang C.I.
Structure of yeast Ape1 and its role in autophagic vesicle formation.
Autophagy
11
1580-1593
2015
430848
Yamasaki A.,Watanabe Y.,Adachi W.,Suzuki K.,Matoba K.,Kirisako H.,Kumeta H.,Nakatogawa H.,Ohsumi Y.,Inagaki F.,Noda N.N.
Structural basis for receptor-mediated selective autophagy of aminopeptidase I aggregates.
Cell Rep.
16
19-27
2016
430849
Bertipaglia C.,Schneider S.,Jakobi A.J.,Tarafder A.K.,Bykov Y.S.,Picco A.,Kukulski W.,Kosinski J.,Hagen W.J.,Ravichandran A.C.,Wilmanns M.,Wilmanns M.,Kaksonen M.,Briggs J.A.,Sachse C.
Higher-order assemblies of oligomeric cargo receptor complexes form the membrane scaffold of the Cvt vesicle.
EMBO Rep.
17
1044-1060
2016
