Sequence of AL3A1_RAT
EC Number:1.2.1.5
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + H+
General information:
Sequence
0 MSSISDTVKR AREAFNSGKT RSLQFRIQQL EALQRMINEN LKSISGALAS DLGKNEWTSY
60 YEEVAHVLEE LDTTIKELPD WAEDEPVAKT RQTQQDDLYI HSEPLGVVLV IGAWNYPFNL
120 TIQPMVGAVA AGNAVILKPS EVSGHMADLL ATLIPQYMDQ NLYLVVKGGV PETTELLKER
180 FDHIMYTGST AVGKIVMAAA AKHLTPVTLE LGGKSPCYVD KDCDLDVACR RIAWGKFMNS
240 GQTCVAPDYI LCDPSIQNQI VEKLKKSLKD FYGEDAKQSR DYGRIINDRH FQRVKGLIDN
300 QKVAHGGTWD QSSRYIAPTI LVDVDPQSPV MQEEIFGPVM PIVCVRSLEE AIQFINQREK
360 PLALYVFSNN EKVIKKMIAE TSSGGVTAND VIVHITVPTL PFGGVGNSGM GAYHGKKSFE
420 TFSHRRSCLV KSLLNEEAHK ARYPPSPAKM PRH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
418094
Jones D.E.,Brennan M.D.,Hempel J.,Lindahl R.
Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase.
Proc. Natl. Acad. Sci. U.S.A.
85
1782-1786
1988
418095
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
418096
Hempel J.,Harper K.,Lindahl R.
Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria.
Biochemistry
28
1160-1167
1989
418097
Asman D.C.,Takimoto K.,Pitot H.C.,Dunn T.J.,Lindahl R.
Organization and characterization of the rat class 3 aldehyde dehydrogenase gene.
J. Biol. Chem.
268
12530-12536
1993
418098
Rose J.P.,Hempel J.,Kuo I.,Lindahl R.,Wang B.-C.
Preliminary crystallographic analysis of class 3 rat liver aldehyde dehydrogenase.
Proteins
8
305-308
1990
418099
Liu Z.-J.,Sun Y.J.,Rose J.P.,Chung Y.-J.,Hsiao C.D.,Chang W.-R.,Kuo I.,Perozich J.,Lindahl R.,Hempel J.,Wang B.-C.
The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold.
Nat. Struct. Biol.
4
317-326
1997
