Sequence of EASA_ASPFU

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
chanoclavine-I aldehyde reductase
Q4WZ70
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
376
42186
Reaction
dihydrochanoclavine-I aldehyde + NADP+ = chanoclavine-I aldehyde + NADPH + H+
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MREEPSSAQL FKPLKVGRCH LQHRMIMAPT TRFRADGQGV PLPFVQEYYG QRASVPGTLL
 60 ITEATDITPK AMGYKHVPGI WSEPQREAWR EIVSRVHSKK CFIFCQLWAT GRAADPDVLA
120 DMKDLISSSA VPVEEKGPLP RALTEDEIQQ CIADFAQAAR NAINAGFDGV EIHGANGYLI
180 DQFTQKSCNH RQDRWGGSIE NRARFAVEVT RAVIEAVGAD RVGVKLSPYS QYLGMGTMDE
240 LVPQFEYLIA QMRRLDVAYL HLANSRWLDE EKPHPDPNHE VFVRVWGQSS PILLAGGYDA
300 ASAEKVTEQM AAATYTNVAI AFGRYFISTP DLPFRVMAGI QLQKYDRASF YSTLSREGYL
360 DYPFSAEYMA LHNFPV
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
529573
Nierman W.C.,Pain A.,Anderson M.J.,Wortman J.R.,Kim H.S.,Arroyo J.,Berriman M.,Abe K.,Archer D.B.,Bermejo C.,Bennett J.W.,Bowyer P.,Chen D.,Collins M.,Coulsen R.,Davies R.,Dyer P.S.,Farman M.L.,Fedorova N.,Fedorova N.D.,Feldblyum T.V.,Fischer R.,Fosker N.,Fraser A.,Garcia J.L.,Garcia M.J.,Goble A.,Goldman G.H.,Gomi K.,Griffith-Jones S.,Gwilliam R.,Haas B.J.,Haas H.,Harris D.E.,Horiuchi H.,Huang J.,Humphray S.,Jimenez J.,Keller N.,Khouri H.,Kitamoto K.,Kobayashi T.,Konzack S.,Kulkarni R.,Kumagai T.,Lafton A.,Latge J.-P.,Li W.,Lord A.,Lu C.,Majoros W.H.,May G.S.,Miller B.L.,Mohamoud Y.,Molina M.,Monod M.,Mouyna I.,Mulligan S.,Murphy L.D.,O'Neil S.,Paulsen I.,Penalva M.A.,Pertea M.,Price C.,Pritchard B.L.,Quail M.A.,Rabbinowitsch E.,Rawlins N.,Rajandream M.A.,Reichard U.,Renauld H.,Robson G.D.,Rodriguez de Cordoba S.,Rodriguez-Pena J.M.,Ronning C.M.,Rutter S.,Salzberg S.L.,Sanchez M.,Sanchez-Ferrero J.C.,Saunders D.,Seeger K.,Squares R.,Squares S.,Takeuchi M.,Tekaia F.,Turner G.,Vazquez de Aldana C.R.,Weidman J.,White O.,Woodward J.R.,Yu J.-H.,Fraser C.M.,Galagan J.E.,Asai K.,Machida M.,Hall N.,Barrell B.G.,Denning D.W.
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.
Nature
438
1151-1156
2005
529574
Coyle C.M.,Panaccione D.G.
An ergot alkaloid biosynthesis gene and clustered hypothetical genes from Aspergillus fumigatus.
Appl. Environ. Microbiol.
71
3112-3118
2005
529575
Unsoeld I.A.,Li S.-M.
Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus.
Microbiology
151
1499-1505
2005
529576
Liu X.,Wang L.,Steffan N.,Yin W.B.,Li S.M.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses the acetylation of fumigaclavine B.
ChemBioChem
10
2325-2328
2009
529577
Twumasi-Boateng K.,Yu Y.,Chen D.,Gravelat F.N.,Nierman W.C.,Sheppard D.C.
Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus.
Eukaryot. Cell
8
104-115
2009
529578
Haarmann T.,Rolke Y.,Giesbert S.,Tudzynski P.
Ergot: from witchcraft to biotechnology.
Mol. Plant Pathol.
10
563-577
2009
529579
Wallwey C.,Matuschek M.,Li S.M.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
Arch. Microbiol.
192
127-134
2010
529580
Wallwey C.,Matuschek M.,Xie X.L.,Li S.M.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3.
Org. Biomol. Chem.
8
3500-3508
2010
529581
Goetz K.E.,Coyle C.M.,Cheng J.Z.,O'Connor S.E.,Panaccione D.G.
Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus.
Curr. Genet.
57
201-211
2011
529582
Xie X.,Wallwey C.,Matuschek M.,Steinbach K.,Li S.M.
Formyl migration product of chanoclavine-I aldehyde in the presence of the old yellow enzyme FgaOx3 from Aspergillus fumigatus: a NMR structure elucidation.
Magn. Reson. Chem.
49
678-681
2011
529583
Robinson S.L.,Panaccione D.G.
Chemotypic and genotypic diversity in the ergot alkaloid pathway of Aspergillus fumigatus.
Mycologia
104
804-812
2012
529584
Bilovol Y.,Panaccione D.G.
Functional analysis of the gene controlling hydroxylation of festuclavine in the ergot alkaloid pathway of Neosartorya fumigata.
Curr. Genet.
62
853-860
2016
529585
Chilton A.S.,Ellis A.L.,Lamb A.L.
Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis.
Acta Crystallogr. F Struct. Biol. Commun.
70
1328-1332
2014