Sequence of COABC_ECOLI
EC Number:6.3.2.5
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
General information:
Sequence
0 MSLAGKKIVL GVSGGIAAYK TPELVRRLRD RGADVRVAMT EAAKAFITPL SLQAVSGYPV
60 SDSLLDPAAE AAMGHIELGK WADLVILAPA TADLIARVAA GMANDLVSTI CLATPAPVAV
120 LPAMNQQMYR AAATQHNLEV LASRGLLIWG PDSGSQACGD IGPGRMLDPL TIVDMAVAHF
180 SPVNDLKHLN IMITAGPTRE PLDPVRYISN HSSGKMGFAI AAAAARRGAN VTLVSGPVSL
240 PTPPFVKRVD VMTALEMEAA VNASVQQQNI FIGCAAVADY RAATVAPEKI KKQATQGDEL
300 TIKMVKNPDI VAGVAALKDH RPYVVGFAAE TNNVEEYARQ KRIRKNLDLI CANDVSQPTQ
360 GFNSDNNALH LFWQDGDKVL PLERKELLGQ LLLDEIVTRY DEKNRR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
381004
Burland V.D.,Plunkett G. III,Daniels D.L.,Blattner F.R.
DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.
Genomics
16
551-561
1993
381005
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
381006
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
E1-E5
2006
381007
Kupke T.,Uebele M.,Schmid D.,Jung G.,Blaesse M.,Steinbacher S.
Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis.
J. Biol. Chem.
275
31838-31846
2000
381008
Lundberg L.G.,Thoresson H.-O.,Karlstroem O.H.,Nyman P.O.
Nucleotide sequence of the structural gene for dUTPase of Escherichia coli K-12.
EMBO J.
2
967-971
1983
381009
Strauss E.,Kinsland C.,Ge Y.,McLafferty F.W.,Begley T.P.
Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria.
J. Biol. Chem.
276
13513-13516
2001
381010
Kupke T.
Molecular characterization of the 4'-phosphopantothenoylcysteine decarboxylase domain of bacterial Dfp flavoproteins.
J. Biol. Chem.
276
27597-27604
2001
381011
Kupke T.
Molecular characterization of the 4'-phosphopantothenoylcysteine synthetase domain of bacterial dfp flavoproteins.
J. Biol. Chem.
277
36137-36145
2002
381012
Kupke T.
Active-site residues and amino acid specificity of the bacterial 4'-phosphopantothenoylcysteine synthetase CoaB.
Eur. J. Biochem.
271
163-172
2004
381013
Stanitzek S.,Augustin M.A.,Huber R.,Kupke T.,Steinbacher S.
Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase.
Structure
12
1977-1988
2004
