Sequence of PPBT_MOUSE
EC Number:3.1.3.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a phosphate monoester + H2O = an alcohol + phosphate
General information:
Sequence
0 MISPFLVLAI GTCLTNSFVP EKERDPSYWR QQAQETLKNA LKLQKLNTNV AKNVIMFLGD
60 GMGVSTVTAA RILKGQLHHN TGEETRLEMD KFPFVALSKT YNTNAQVPDS AGTATAYLCG
120 VKANEGTVGV SAATERTRCN TTQGNEVTSI LRWAKDAGKS VGIVTTTRVN HATPSAAYAH
180 SADRDWYSDN EMPPEALSQG CKDIAYQLMH NIKDIDVIMG GGRKYMYPKN RTDVEYELDE
240 KARGTRLDGL DLISIWKSFK PRHKHSHYVW NRTELLALDP SRVDYLLGLF EPGDMQYELN
300 RNNLTDPSLS EMVEVALRIL TKNLKGFFLL VEGGRIDHGH HEGKAKQALH EAVEMDQAIG
360 KAGAMTSQKD TLTVVTADHS HVFTFGGYTP RGNSIFGLAP MVSDTDKKPF TAILYGNGPG
420 YKVVDGEREN VSMVDYAHNN YQAQSAVPLR HETHGGEDVA VFAKGPMAHL LHGVHEQNYI
480 PHVMAYASCI GANLDHCAWA GSGSAPSPGA LLLPLAVLSL RTLF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
365267
Terao M.,Mintz B.
Cloning and characterization of a cDNA coding for mouse placental alkaline phosphatase.
Proc. Natl. Acad. Sci. U.S.A.
84
7051-7055
1987
365268
Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.
The transcriptional landscape of the mammalian genome.
Science
309
1559-1563
2005
365269
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
E1000112-E1000112
2009
365270
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
365271
Brown N.A.,Stofko R.E.,Uhler M.D.
Induction of alkaline phosphatase in mouse L cells by overexpression of the catalytic subunit of cAMP-dependent protein kinase.
J. Biol. Chem.
265
13181-13189
1990
365272
MacGregor G.R.,Zambrowicz B.P.,Soriano P.
Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells.
Development
121
1487-1496
1995
365273
Waymire K.G.,Mahuren J.D.,Jaje J.M.,Guilarte T.R.,Coburn S.P.,MacGregor G.R.
Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.
Nat. Genet.
11
45-51
1995
365274
Narisawa S.,Froehlander N.,Millan J.L.
Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.
Dev. Dyn.
208
432-446
1997
365275
Fedde K.N.,Blair L.,Silverstein J.,Coburn S.P.,Ryan L.M.,Weinstein R.S.,Waymire K.,Narisawa S.,Millan J.L.,MacGregor G.R.,Whyte M.P.
Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia.
J. Bone Miner. Res.
14
2015-2026
1999
365276
Johnson K.A.,Hessle L.,Vaingankar S.,Wennberg C.,Mauro S.,Narisawa S.,Goding J.W.,Sano K.,Millan J.L.,Terkeltaub R.
Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1.
Am. J. Physiol.
279
R1365-R1377
2000
365277
Wennberg C.,Hessle L.,Lundberg P.,Mauro S.,Narisawa S.,Lerner U.H.,Millan J.L.
Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice.
J. Bone Miner. Res.
15
1879-1888
2000
365278
Narisawa S.,Wennberg C.,Millan J.L.
Abnormal vitamin B6 metabolism in alkaline phosphatase knock-out mice causes multiple abnormalities, but not the impaired bone mineralization.
J. Pathol.
193
125-133
2001
365279
Hessle L.,Johnson K.A.,Anderson H.C.,Narisawa S.,Sali A.,Goding J.W.,Terkeltaub R.,Millan J.L.
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization.
Proc. Natl. Acad. Sci. U.S.A.
99
9445-9449
2002
365280
Anderson H.C.,Sipe J.B.,Hessle L.,Dhanyamraju R.,Atti E.,Camacho N.P.,Millan J.L.,Dhamyamraju R.
Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice.
Am. J. Pathol.
164
841-847
2004
365281
Wollscheid B.,Bausch-Fluck D.,Henderson C.,O'Brien R.,Bibel M.,Schiess R.,Aebersold R.,Watts J.D.
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
Nat. Biotechnol.
27
378-386
2009
365282
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
365283
Ciancaglini P.,Yadav M.C.,Simao A.M.,Narisawa S.,Pizauro J.M.,Farquharson C.,Hoylaerts M.F.,Millan J.L.
Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles.
J. Bone Miner. Res.
25
716-723
2010
365284
Yadav M.C.,Simao A.M.,Narisawa S.,Huesa C.,McKee M.D.,Farquharson C.,Millan J.L.
Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification.
J. Bone Miner. Res.
26
286-297
2011
365285
Simao A.M.,Bolean M.,Hoylaerts M.F.,Millan J.L.,Ciancaglini P.
Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics.
Calcif. Tissue Int.
93
222-232
2013
365286
Feng X.Y.,Zhao Y.M.,Wang W.J.,Ge L.H.
Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture.
Eur. J. Oral Sci.
121
412-420
2013
365287
Narisawa S.,Yadav M.C.,Millan J.L.
In vivo overexpression of tissue-nonspecific alkaline phosphatase increases skeletal mineralization and affects the phosphorylation status of osteopontin.
J. Bone Miner. Res.
28
1587-1598
2013
365288
Street S.E.,Kramer N.J.,Walsh P.L.,Taylor-Blake B.,Yadav M.C.,King I.F.,Vihko P.,Wightman R.M.,Millan J.L.,Zylka M.J.
Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.
J. Neurosci.
33
11314-11322
2013
365289
Huesa C.,Houston D.,Kiffer-Moreira T.,Yadav M.M.,Millan J.L.,Farquharson C.
The functional co-operativity of Tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 during initiation of skeletal mineralization.
Biochem. Biophys. Rep.
4
196-201
2015
365290
Pinkerton A.B.,Sergienko E.,Bravo Y.,Dahl R.,Ma C.T.,Sun Q.,Jackson M.R.,Cosford N.D.P.,Millan J.L.
Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.
Bioorg. Med. Chem. Lett.
28
31-34
2018
365291
Feng X.Y.,Wu X.S.,Wang J.S.,Zhang C.M.,Wang S.L.
Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage.
Eur. J. Oral Sci.
126
1-12
2018
365292
Nakamura T.,Nakamura-Takahashi A.,Kasahara M.,Yamaguchi A.,Azuma T.
Tissue-nonspecific alkaline phosphatase promotes the osteogenic differentiation of osteoprogenitor cells.
Biochem. Biophys. Res. Commun.
524
702-709
2020
365293
Bessueille L.,Briolay A.,Como J.,Mebarek S.,Mansouri C.,Gleizes M.,El Jamal A.,Buchet R.,Dumontet C.,Matera E.L.,Mornet E.,Millan J.L.,Fonta C.,Magne D.
Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase.
Bone
133
115262-115262
2020
365294
Sun Y.,Rahbani J.F.,Jedrychowski M.P.,Riley C.L.,Vidoni S.,Bogoslavski D.,Hu B.,Dumesic P.A.,Zeng X.,Wang A.B.,Knudsen N.H.,Kim C.R.,Marasciullo A.,Millan J.L.,Chouchani E.T.,Kazak L.,Spiegelman B.M.
Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Nature
593
580-585
2021
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