Sequence of BAP1_HUMAN
EC Number:3.4.19.12
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Other sequences found for EC No. 3.4.19.12
General information:
Sequence
0 MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR
60 KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSSVDLGP TLSRMKDFTK
120 GFSPESKGYA IGNAPELAKA HNSHARPEPR HLPEKQNGLS AVRTMEAFHF VSYVPITGRL
180 FELDGLKVYP IDHGPWGEDE EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRIK
240 YEARLHVLKV NRQTVLEALQ QLIRVTQPEL IQTHKSQESQ LPEESKSASN KSPLVLEANR
300 APAASEGNHT DGAEEAAGSC AQAPSHSPPN KPKLVVKPPG SSLNGVHPNP TPIVQRLPAF
360 LDNHNYAKSP MQEEEDLAAG VGRSRVPVRP PQQYSDDEDD YEDDEEDDVQ NTNSALRYKG
420 KGTGKPGALS GSADGQLSVL QPNTINVLAE KLKESQKDLS IPLSIKTSSG AGSPAVAVPT
480 HSQPSPTPSN ESTDTASEIG SAFNSPLRSP IRSANPTRPS SPVTSHISKV LFGEDDSLLR
540 VDCIRYNRAV RDLGPVISTG LLHLAEDGVL SPLALTEGGK GSSPSIRPIQ GSQGSSSPVE
600 KEVVEATDSR EKTGMVRPGE PLSGEKYSPK ELLALLKCVE AEIANYEACL KEEVEKRKKF
660 KIDDQRRTHN YDEFICTFIS MLAQEGMLAN LVEQNISVRR RQGVSIGRLH KQRKPDRRKR
720 SRPYKAKRQ
Download this sequence
in fasta formatDownload all sequences for 3.4.19.12
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
519322
Jensen D.E.,Proctor M.,Marquis S.T.,Gardner H.P.,Ha S.I.,Chodosh L.A.,Ishov A.M.,Tommerup N.,Vissing H.,Sekido Y.,Minna J.,Borodovsky A.,Schultz D.C.,Wilkinson K.D.,Maul G.G.,Barlev N.,Berger S.,Prendergast G.C.,Rauscher F.J. III
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
Oncogene
16
1097-1112
1998
519324
Nagase T.,Seki N.,Ishikawa K.,Ohira M.,Kawarabayasi Y.,Ohara O.,Tanaka A.,Kotani H.,Miyajima N.,Nomura N.
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
DNA Res.
3
321-329
1996
519325
Nakajima D.,Okazaki N.,Yamakawa H.,Kikuno R.,Ohara O.,Nagase T.
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
DNA Res.
9
99-106
2002
519326
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
519328
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
519329
Behrends U.,Schneider I.,Roessler S.,Frauenknecht H.,Golbeck A.,Lechner B.,Eigenstetter G.,Zobywalski C.,Mueller-Weihrich S.,Graubner U.,Schmid I.,Sackerer D.,Spaeth M.,Goetz C.,Prantl F.,Asmuss H.-P.,Bise K.,Mautner J.
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.
Int. J. Cancer
106
244-251
2003
519330
Cantin G.T.,Yi W.,Lu B.,Park S.K.,Xu T.,Lee J.-D.,Yates J.R. III
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
J. Proteome Res.
7
1346-1351
2008
519331
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
519332
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
519333
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
519334
Bott M.,Brevet M.,Taylor B.S.,Shimizu S.,Ito T.,Wang L.,Creaney J.,Lake R.A.,Zakowski M.F.,Reva B.,Sander C.,Delsite R.,Powell S.,Zhou Q.,Shen R.,Olshen A.,Rusch V.,Ladanyi M.
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Nat. Genet.
43
668-672
2011
519335
Wiesner T.,Obenauf A.C.,Murali R.,Fried I.,Griewank K.G.,Ulz P.,Windpassinger C.,Wackernagel W.,Loy S.,Wolf I.,Viale A.,Lash A.E.,Pirun M.,Socci N.D.,Rutten A.,Palmedo G.,Abramson D.,Offit K.,Ott A.,Becker J.C.,Cerroni L.,Kutzner H.,Bastian B.C.,Speicher M.R.
Germline mutations in BAP1 predispose to melanocytic tumors.
Nat. Genet.
43
1018-1021
2011
519336
Testa J.R.,Cheung M.,Pei J.,Below J.E.,Tan Y.,Sementino E.,Cox N.J.,Dogan A.U.,Pass H.I.,Trusa S.,Hesdorffer M.,Nasu M.,Powers A.,Rivera Z.,Comertpay S.,Tanji M.,Gaudino G.,Yang H.,Carbone M.
Germline BAP1 mutations predispose to malignant mesothelioma.
Nat. Genet.
43
1022-1025
2011
519337
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
519338
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
519339
Jensen D.E.,Rauscher F.J. III
Defining biochemical functions for the BRCA1 tumor suppressor protein: analysis of the BRCA1 binding protein BAP1.
Cancer Lett.
143
0-0
1999
519340
Mallery D.L.,Vandenberg C.J.,Hiom K.
Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains.
EMBO J.
21
6755-6762
2002
519341
Ventii K.H.,Devi N.S.,Friedrich K.L.,Chernova T.A.,Tighiouart M.,Van Meir E.G.,Wilkinson K.D.
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization.
Cancer Res.
68
6953-6962
2008
519342
Nishikawa H.,Wu W.,Koike A.,Kojima R.,Gomi H.,Fukuda M.,Ohta T.
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.
Cancer Res.
69
111-119
2009
519343
Machida Y.J.,Machida Y.,Vashisht A.A.,Wohlschlegel J.A.,Dutta A.
The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.
J. Biol. Chem.
284
34179-34188
2009
519344
Misaghi S.,Ottosen S.,Izrael-Tomasevic A.,Arnott D.,Lamkanfi M.,Lee J.,Liu J.,O'Rourke K.,Dixit V.M.,Wilson A.C.
Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1.
Mol. Cell. Biol.
29
2181-2192
2009
519345
Scheuermann J.C.,de Ayala Alonso A.G.,Oktaba K.,Ly-Hartig N.,McGinty R.K.,Fraterman S.,Wilm M.,Muir T.W.,Muller J.
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB.
Nature
465
243-247
2010
519346
Mashtalir N.,Daou S.,Barbour H.,Sen N.N.,Gagnon J.,Hammond-Martel I.,Dar H.H.,Therrien M.,Affar E.B.
Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.
Mol. Cell
54
392-406
2014
519347
Ji Z.,Mohammed H.,Webber A.,Ridsdale J.,Han N.,Carroll J.S.,Sharrocks A.D.
The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.
Nucleic Acids Res.
42
6232-6242
2014
519348
Okino Y.,Machida Y.,Frankland-Searby S.,Machida Y.J.
BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genes.
J. Biol. Chem.
290
1580-1591
2015
519349
de la Fouchardiere A.,Cabaret O.,Savin L.,Combemale P.,Schvartz H.,Penet C.,Bonadona V.,Soufir N.,Bressac-de Paillerets B.
Germline BAP1 mutations predispose also to multiple basal cell carcinomas.
Clin. Genet.
88
273-277
2015
519350
Bhattacharya S.,Hanpude P.,Maiti T.K.
Cancer associated missense mutations in BAP1 catalytic domain induce amyloidogenic aggregation: A new insight in enzymatic inactivation.
Sci. Rep.
5
18462-18462
2015
