Sequence of DHPS_STRPN
EC Number:2.5.1.15
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
dihydropteroate synthase
P05382
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
314
34403
Reaction
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate
General information:
Sequence
0 MSSKANHAKT VICGIINVTP DSFSDGGQFF ALEQALQQAR KLIAEGASML DIGGESTRPG
60 SSYVEIEEEI QRVVPVIKAI RKESDVLISI DTWKSQVAEA ALAAGADLVN DITGLMGDEK
120 MAYVVAEARA KVVIMFNPVM ARPQHPSSLI FPHFGFGQTF TEKELADFET LPIEDLMVAF
180 FERALARAAE AGIAPENILL DPGIGFGLTK KENLLLLRDL DKLHQKGYPI FLGVSRKRFV
240 INILEENGFE VNPETELGFR NRDTASAHVT SIAARQGVEV VRVHDVASHR MAVEIASAIR
300 LADEAENLDL KQYK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
345167
Lopez P.,Espinosa M.,Greenberg B.,Lacks S.A.
Sulfonamide resistance in Streptococcus pneumoniae: DNA sequence of the gene encoding dihydropteroate synthase and characterization of the enzyme.
J. Bacteriol.
169
4320-4326
1987
345168
Tettelin H.,Nelson K.E.,Paulsen I.T.,Eisen J.A.,Read T.D.,Peterson S.N.,Heidelberg J.F.,DeBoy R.T.,Haft D.H.,Dodson R.J.,Durkin A.S.,Gwinn M.L.,Kolonay J.F.,Nelson W.C.,Peterson J.D.,Umayam L.A.,White O.,Salzberg S.L.,Lewis M.R.,Radune D.,Holtzapple E.K.,Khouri H.M.,Wolf A.M.,Utterback T.R.,Hansen C.L.,McDonald L.A.,Feldblyum T.V.,Angiuoli S.V.,Dickinson T.,Hickey E.K.,Holt I.E.,Loftus B.J.,Yang F.,Smith H.O.,Venter J.C.,Dougherty B.A.,Morrison D.A.,Hollingshead S.K.,Fraser C.M.
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.
Science
293
498-506
2001
