Sequence of DES7_STRVZ

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
10-deoxymethynolide desosaminyltransferase
Q9ZGH7
Streptomyces venezuelae
426
46423
Reaction
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide = dTDP + 10-deoxymethymycin
Sequences with same EC No.
Sequence
  0 MRVLLTSFAH HTHYYGLVPL AWALLAAGHE VRVASQPALT DTITGSGLAA VPVGTDHLIH
 60 EYRVRMAGEP RPNHPAIAFD EARPEPLDWD HALGIEAILA PYFHLLANND SMVDDLVDFA
120 RSWQPDLVLW EPTTYAGAVA AQVTGAAHAR VLWGPDVMGS ARRKFVALRD RQPPEHREDP
180 TAEWLTWTLD RYGASFEEEL LTGQFTIDPT PPSLRLDTGL PTVGMRYVPY NGTSVVPDWL
240 SEPPARPRVC LTLGVSAREV LGGDGVSQGD ILEALADLDI ELVATLDASQ RAEIRNYPKH
300 TRFTDFVPMH ALLPSCSAII HHGGAGTYAT AVINAVPQVM LAELWDAPVK ARAVAEQGAG
360 FFLPPAELTP QAVRDAVVRI LDDPSVATAA HRLREETFGD PTPAGIVPEL ERLAAQHRRP
420 PADARH
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1119490
Xue Y.,Zhao L.,Liu H.W.,Sherman D.H.
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
Proc. Natl. Acad. Sci. U.S.A.
95
12111-12116
1998
1119491
Borisova S.A.,Zhao L.,Melancon C.E. III,Kao C.L.,Liu H.W.
Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.
J. Am. Chem. Soc.
126
6534-6535
2004
1119492
Borisova S.A.,Zhang C.,Takahashi H.,Zhang H.,Wong A.W.,Thorson J.S.,Liu H.W.
Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses.
Angew. Chem. Int. Ed.
45
2748-2753
2006
1119493
Hong J.S.,Park S.J.,Parajuli N.,Park S.R.,Koh H.S.,Jung W.S.,Choi C.Y.,Yoon Y.J.
Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation.
Gene
386
123-130
2007
1119494
Borisova S.A.,Kim H.J.,Pu X.,Liu H.W.
Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications.
ChemBioChem
9
1554-1558
2008
1119495
Borisova S.A.,Liu H.W.
Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway.
Biochemistry
49
8071-8084
2010