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Sequence of PON1_HUMAN

EC Number:3.1.1.2

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
arylesterase
P27169
Homo sapiens
355
39731
Reaction
a phenyl acetate + H2O = a phenol + acetate
Other sequences found for EC No. 3.1.1.2

EC Number:3.1.1.25

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
1,4-lactonase
P27169
Homo sapiens
355
39731
Reaction
a 1,4-lactone + H2O = a 4-hydroxyacid
Other sequences found for EC No. 3.1.1.25

EC Number:3.1.1.81

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
quorum-quenching N-acyl-homoserine lactonase
P27169
Homo sapiens
355
39731
Reaction
an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine
Other sequences found for EC No. 3.1.1.81

EC Number:3.1.8.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
aryldialkylphosphatase
P27169
Homo sapiens
355
39731
Reaction
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
Other sequences found for EC No. 3.1.8.1

EC Number:3.1.8.2

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
diisopropyl-fluorophosphatase
P27169
Homo sapiens
355
39731
Reaction
diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride
Other sequences found for EC No. 3.1.8.2

General information:

Sequence
show sequence in fasta format
  0 MAKLIALTLL GMGLALFRNH QSSYQTRLNA LREVQPVELP NCNLVKGIET GSEDLEILPN
 60 GLAFISSGLK YPGIKSFNPN SPGKILLMDL NEEDPTVLEL GITGSKFDVS SFNPHGISTF
120 TDEDNAMYLL VVNHPDAKST VELFKFQEEE KSLLHLKTIR HKLLPNLNDI VAVGPEHFYG
180 TNDHYFLDPY LQSWEMYLGL AWSYVVYYSP SEVRVVAEGF DFANGINISP DGKYVYIAEL
240 LAHKIHVYEK HANWTLTPLK SLDFNTLVDN ISVDPETGDL WVGCHPNGMK IFFYDSENPP
300 ASEVLRIQNI LTEEPKVTQV YAENGTVLQG STVASVYKGK LLIGTVFHKA LYCEL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
714639
Hassett C.,Richter R.J.,Humbert R.,Chapline C.,Crabb J.W.,Omiecinski C.J.,Furlong C.E.
Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence.
Biochemistry
30
10141-10149
1991
714640
Adkins S.,Gan K.N.,Mody M.,La Du B.N.
Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.
Am. J. Hum. Genet.
52
598-608
1993
714641
La Du B.N.,Adkins S.,Kuo C.L.,Lipsig D.
Studies on human serum paraoxonase/arylesterase.
Chem. Biol. Interact.
87
25-34
1993
714642
Furlong C.E.,Costa L.G.,Hassett C.,Richter R.J.,Sundstrom J.A.,Adler D.A.,Disteche C.M.,Omiecinski C.J.,Chapline C.,Crabb J.W.
Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification.
Chem. Biol. Interact.
87
35-48
1993
714643
Clendenning J.B.,Humbert R.,Green E.D.,Wood C.,Traver D.,Furlong C.E.
Structural organization of the human PON1 gene.
Genomics
35
586-589
1996
714644
Wang K.K.,Wan D.F.,Qiu X.K.,Lu P.X.,Gu J.R.
Differential expression of a cDNA clone in human liver versus hepatic cancer -- highly homologous to aryl-dialkyl-phosphatase.
Cell Res.
7
79-90
1997
714645
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
714647
Hillier L.W.,Fulton R.S.,Fulton L.A.,Graves T.A.,Pepin K.H.,Wagner-McPherson C.,Layman D.,Maas J.,Jaeger S.,Walker R.,Wylie K.,Sekhon M.,Becker M.C.,O'Laughlin M.D.,Schaller M.E.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Cordes M.,Du H.,Sun H.,Edwards J.,Bradshaw-Cordum H.,Ali J.,Andrews S.,Isak A.,Vanbrunt A.,Nguyen C.,Du F.,Lamar B.,Courtney L.,Kalicki J.,Ozersky P.,Bielicki L.,Scott K.,Holmes A.,Harkins R.,Harris A.,Strong C.M.,Hou S.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Leonard S.,Rohlfing T.,Rock S.M.,Tin-Wollam A.-M.,Abbott A.,Minx P.,Maupin R.,Strowmatt C.,Latreille P.,Miller N.,Johnson D.,Murray J.,Woessner J.P.,Wendl M.C.,Yang S.-P.,Schultz B.R.,Wallis J.W.,Spieth J.,Bieri T.A.,Nelson J.O.,Berkowicz N.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Bedell J.A.,Mardis E.R.,Clifton S.W.,Chissoe S.L.,Marra M.A.,Raymond C.,Haugen E.,Gillett W.,Zhou Y.,James R.,Phelps K.,Iadanoto S.,Bubb K.,Simms E.,Levy R.,Clendenning J.,Kaul R.,Kent W.J.,Furey T.S.,Baertsch R.A.,Brent M.R.,Keibler E.,Flicek P.,Bork P.,Suyama M.,Bailey J.A.,Portnoy M.E.,Torrents D.,Chinwalla A.T.,Gish W.R.,Eddy S.R.,McPherson J.D.,Olson M.V.,Eichler E.E.,Green E.D.,Waterston R.H.,Wilson R.K.
The DNA sequence of human chromosome 7.
Nature
424
157-164
2003
714648
Scherer S.W.,Cheung J.,MacDonald J.R.,Osborne L.R.,Nakabayashi K.,Herbrick J.-A.,Carson A.R.,Parker-Katiraee L.,Skaug J.,Khaja R.,Zhang J.,Hudek A.K.,Li M.,Haddad M.,Duggan G.E.,Fernandez B.A.,Kanematsu E.,Gentles S.,Christopoulos C.C.,Choufani S.,Kwasnicka D.,Zheng X.H.,Lai Z.,Nusskern D.R.,Zhang Q.,Gu Z.,Lu F.,Zeesman S.,Nowaczyk M.J.,Teshima I.,Chitayat D.,Shuman C.,Weksberg R.,Zackai E.H.,Grebe T.A.,Cox S.R.,Kirkpatrick S.J.,Rahman N.,Friedman J.M.,Heng H.H.Q.,Pelicci P.G.,Lo-Coco F.,Belloni E.,Shaffer L.G.,Pober B.,Morton C.C.,Gusella J.F.,Bruns G.A.P.,Korf B.R.,Quade B.J.,Ligon A.H.,Ferguson H.,Higgins A.W.,Leach N.T.,Herrick S.R.,Lemyre E.,Farra C.G.,Kim H.-G.,Summers A.M.,Gripp K.W.,Roberts W.,Szatmari P.,Winsor E.J.T.,Grzeschik K.-H.,Teebi A.,Minassian B.A.,Kere J.,Armengol L.,Pujana M.A.,Estivill X.,Wilson M.D.,Koop B.F.,Tosi S.,Moore G.E.,Boright A.P.,Zlotorynski E.,Kerem B.,Kroisel P.M.,Petek E.,Oscier D.G.,Mould S.J.,Doehner H.,Doehner K.,Rommens J.M.,Vincent J.B.,Venter J.C.,Li P.W.,Mural R.J.,Adams M.D.,Tsui L.-C.
Human chromosome 7: DNA sequence and biology.
Science
300
767-772
2003
714650
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
714651
Blatter M.-C.,James R.W.,Messmer S.,Barja F.,Pometta D.
Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase.
Eur. J. Biochem.
211
871-879
1993
714652
Kelso G.J.,Stuart W.D.,Richter R.J.,Furlong C.E.,Jordan-Starck T.C.,Harmony J.A.K.
Apolipoprotein J is associated with paraoxonase in human plasma.
Biochemistry
33
832-839
1994
714653
Furlong C.E.,Richter R.J.,Chapline C.,Crabb J.W.
Purification of rabbit and human serum paraoxonase.
Biochemistry
30
10133-10140
1991
714654
Gan K.N.,Smolen A.,Eckerson H.W.,La Du B.N.
Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.
Drug Metab. Dispos.
19
100-106
1991
714655
Sorenson R.C.,Primo-Parmo S.L.,Kuo C.-L.,Adkins S.,Lockridge O.,La Du B.N.
Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase.
Proc. Natl. Acad. Sci. U.S.A.
92
7187-7191
1995
714656
Sorenson R.C.,Bisgaier C.L.,Aviram M.,Hsu C.,Billecke S.,La Du B.N.
Human serum paraoxonase/arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids: apolipoprotein A-I stabilizes activity.
Arterioscler. Thromb. Vasc. Biol.
19
2214-2225
1999
714657
Bunkenborg J.,Pilch B.J.,Podtelejnikov A.V.,Wisniewski J.R.
Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
Proteomics
4
454-465
2004
714658
Draganov D.I.,Teiber J.F.,Speelman A.,Osawa Y.,Sunahara R.,La Du B.N.
Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities.
J. Lipid Res.
46
1239-1247
2005
714659
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
714660
Morales R.,Berna A.,Carpentier P.,Contreras-Martel C.,Renault F.,Nicodeme M.,Chesne-Seck M.-L.,Bernier F.,Dupuy J.,Schaeffer C.,Diemer H.,van Dorsselaer A.,Fontecilla-Camps J.C.,Masson P.,Rochu D.,Chabriere E.
Serendipitous discovery and X-ray structure of a human phosphate binding apolipoprotein.
Structure
14
601-609
2006
714661
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
714662
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
714663
Harel M.,Aharoni A.,Gaidukov L.,Brumshtein B.,Khersonsky O.,Meged R.,Dvir H.,Ravelli R.B.G.,McCarthy A.,Toker L.,Silman I.,Sussman J.L.,Tawfik D.S.
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.
Nat. Struct. Mol. Biol.
11
412-419
2004
7146