Sequence of HXK4_RAT
EC Number:2.7.1.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + D-glucose = ADP + D-glucose 6-phosphate
Other sequences found for EC No. 2.7.1.1
General information:
Sequence
0 MLDDRARMEA TKKEKVEQIL AEFQLQEEDL KKVMSRMQKE MDRGLRLETH EEASVKMLPT
60 YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEAGQWS VKTKHQMYSI PEDAMTGTAE
120 MLFDYISECI SDFLDKHQMK HKKLPLGFTF SFPVRHEDLD KGILLNWTKG FKASGAEGNN
180 IVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDRQC EVGMIVGTGC NACYMEEMQN
240 VELVEGDEGR MCVNTEWGAF GDSGELDEFL LEYDRMVDES SANPGQQLYE KIIGGKYMGE
300 LVRLVLLKLV DENLLFHGEA SEQLRTRGAF ETRFVSQVES DSGDRKQIHN ILSTLGLRPS
360 VTDCDIVRRA CESVSTRAAH MCSAGLAGVI NRMRESRSED VMRITVGVDG SVYKLHPSFK
420 ERFHASVRRL TPNCEITFIE SEEGSGRGAA LVSAVACKKA CMLAQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
811340
Andreone T.L.,Printz R.L.,Pilkis S.J.,Magnuson M.A.,Granner D.K.
The amino acid sequence of rat liver glucokinase deduced from cloned cDNA.
J. Biol. Chem.
264
363-369
1989
811341
Hayzer D.J.,Iynedjian P.B.
Alternative splicing of glucokinase mRNA in rat liver.
Biochem. J.
270
261-263
1990
811342
Magnuson M.A.,Shelton K.D.
An alternate promoter in the glucokinase gene is active in the pancreatic beta cell.
J. Biol. Chem.
264
15936-15942
1989
811343
Magnuson M.A.,Andeone T.L.,Printz R.L.,Koch S.,Granner D.K.
Rat glucokinase gene: structure and regulation by insulin.
Proc. Natl. Acad. Sci. U.S.A.
86
4838-4842
1989
811344
Noguchi T.,Takenaka M.,Yamada K.,Matsuda T.,Hashimoto M.,Tanaka T.
Characterization of the 5' flanking region of rat glucokinase gene.
Biochem. Biophys. Res. Commun.
164
1247-1252
1989
811345
Hughes S.D.,Quaade C.,Milburn J.L.,Cassidy L.,Newgard C.B.
Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells.
J. Biol. Chem.
266
4521-4530
1991
811346
Cardenas M.L.,Rabajille E.,Niemeyer H.
Fructose is a good substrate for rat liver 'glucokinase' (hexokinase D).
Biochem. J.
222
363-370
1984
811347
Iynedjian P.B.,Moebius G.,Seitz H.J.,Wollheim C.B.,Renold A.E.
Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets.
Proc. Natl. Acad. Sci. U.S.A.
83
1998-2001
1986
811348
de la Iglesia N.,Veiga-da-Cunha M.,Van Schaftingen E.,Guinovart J.J.,Ferrer J.C.
Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.
FEBS Lett.
456
332-338
1999
811349
Monasterio O.,Cardenas M.L.
Kinetic studies of rat liver hexokinase D ('glucokinase') in non-co-operative conditions show an ordered mechanism with MgADP as the last product to be released.
Biochem. J.
371
29-38
2003
811350
Arden C.,Baltrusch S.,Agius L.
Glucokinase regulatory protein is associated with mitochondria in hepatocytes.
FEBS Lett.
580
2065-2070
2006
811351
Hofmeister-Brix A.,Kollmann K.,Langer S.,Schultz J.,Lenzen S.,Baltrusch S.
Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner.
J. Biol. Chem.
288
35824-35839
2013
