Sequence of OAT_HUMAN

EC Number:2.6.1.13

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
ornithine aminotransferase
P04181
Homo sapiens
439
48535
Reaction
L-ornithine + a 2-oxo carboxylate = L-glutamate 5-semialdehyde + an L-amino acid
Other sequences found for EC No. 2.6.1.13

General information:

Sequence
show sequence in fasta format
  0 MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS DDIFEREYKY GAHNYHPLPV
 60 ALERGKGIYL WDVEGRKYFD FLSSYSAVNQ GHCHPKIVNA LKSQVDKLTL TSRAFYNNVL
120 GEYEEYITKL FNYHKVLPMN TGVEAGETAC KLARKWGYTV KGIQKYKAKI VFAAGNFWGR
180 TLSAISSSTD PTSYDGFGPF MPGFDIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV
240 PDPGYLMGVR ELCTRHQVLF IADEIQTGLA RTGRWLAVDY ENVRPDIVLL GKALSGGLYP
300 VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAD KLGIILRNEL
360 MKLPSDVVTA VRGKGLLNAI VIKETKDWDA WKVCLRLRDN GLLAKPTHGD IIRFAPPLVI
420 KEDELRESIE IINKTILSF
Download this sequence
in fasta format
Download all sequences for 2.6.1.13
in fasta format
in csv (Excel, OpenOffice) format
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
194634
Inana G.,Totsuka S.,Redmond M.,Dougherty T.,Nagle J.,Shiono T.,Ohura T.,Kominami E.,Katunuma N.
Molecular cloning of human ornithine aminotransferase mRNA.
Proc. Natl. Acad. Sci. U.S.A.
83
1203-1207
1986
194635
Ramesh V.,Shaffer M.M.,Allaire J.M.,Shih V.E.,Gusella J.F.
Investigation of gyrate atrophy using a cDNA clone for human ornithine aminotransferase.
DNA
5
493-501
1986
194636
Kobayashi T.,Nishii M.,Takagi Y.,Titani T.,Matsuzawa T.
Molecular cloning and nucleotide sequence analysis of mRNA for human kidney ornithine aminotransferase. An examination of ornithine aminotransferase isozymes between liver and kidney.
FEBS Lett.
255
300-304
1989
194637
Mitchell G.A.,Looney J.E.,Brody L.C.,Steel G.,Suchanek M.,Engelhardt J.F.,Willard H.F.,Valle D.
Human ornithine-delta-aminotransferase. cDNA cloning and analysis of the structural gene.
J. Biol. Chem.
263
14288-14295
1988
194638
Zintz C.B.,Inana G.
Analysis of the human ornithine aminotransferase gene family.
Exp. Eye Res.
50
759-770
1990
194639
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
194641
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
194642
Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 10.
Nature
429
375-381
2004
194644
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
194645
Ramesh V.,Gusella J.F.,Shih V.E.
Molecular pathology of gyrate atrophy of the choroid and retina due to ornithine aminotransferase deficiency.
Mol. Biol. Med.
8
81-93
1991
194646
Simmaco M.,John R.A.,Barra D.,Bossa F.
The primary structure of ornithine aminotransferase. Identification of active-site sequence and site of post-translational proteolysis.
FEBS Lett.
199
39-42
1986
194647
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
194648
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
194649
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
194650
Shah S.A.,Shen B.W.,Brunger A.T.
Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition.
Structure
5
1067-1075
1997
194651
Shen B.W.,Hennig M.,Hohenester E.,Jansonius J.N.,Schirmer T.
Crystal structure of human recombinant ornithine aminotransferase.
J. Mol. Biol.
277
81-102
1998
194652
Storici P.,Capitani G.,Mueller R.,Schirmer T.,Jansonius J.N.
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine.
J. Mol. Biol.
285
297-309
1999
194653
Ramesh V.,McClatchey A.I.,Ramesh N.,Benoit L.A.,Berson E.L.,Shih V.E.,Gusella J.F.
Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy.
Proc. Natl. Acad. Sci. U.S.A.
85
3777-3780
1988
194654
Inana G.,Chambers C.,Hotta Y.,Inouye L.,Filpula D.,Pulford S.,Shiono T.
Point mutation affecting processing of the ornithine aminotransferase precursor protein in gyrate atrophy.
J. Biol. Chem.
264
17432-17436
1989
194655
Michaud J.,Brody L.C.,Steel G.,Fontaine G.,Martin L.S.,Valle D.,Mitchell G.
Strand-separating conformational polymorphism analysis: efficacy of detection of point mutations in the human ornithine delta-aminotransferase gene.
Genomics
13
389-394
1992
194656
Brody L.C.,Mitchell G.A.,Obie C.,Michaud J.,Steel G.,Fontaine G.,Robert M.-F.,Sipila I.,Kaiser-Kupfer M.,Valle D.
Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences.
J. Biol. Chem.
267
3302-3307
1992
194657
Michaud J.,Thompson G.N.,Brody L.C.,Steel G.,Obie C.,Fontaine G.,Schappert K.,Keith C.G.,Valle D.,Mitchell G.A.
Pyridoxine-responsive gyrate atrophy of the choroid and retina: clinical and biochemical correlates of the mutation A226V.
Am. J. Hum. Genet.
56
616-622
1995
194658
Kobayashi T.,Ogawa H.,Kasahara M.,Shiozawa Z.,Matsuzawa T.
A single amino acid substitution within the mature sequence of ornithine aminotransferase obstructs mitochondrial entry of the precursor.
Am. J. Hum. Genet.
57
284-291
1995
194659
Doimo M.,Desbats M.A.,Baldoin M.C.,Lenzini E.,Basso G.,Murphy E.,Graziano C.,Seri M.,Burlina A.,Sartori G.,Trevisson E.,Salviati L.
Functional analysis of missense mutations of OAT, causing gyrate atrophy of choroid and retina.
Hum. Mutat.
34
229-236
2013