Sequence of PH4H_RAT

EC Number:1.14.16.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phenylalanine 4-monooxygenase
P04176
Rattus norvegicus
453
51822
Reaction
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
Other sequences found for EC No. 1.14.16.1

General information:

Sequence
show sequence in fasta format
  0 MAAVVLENGV LSRKLSDFGQ ETSYIEDNSN QNGAISLIFS LKEEVGALAK VLRLFEENDI
 60 NLTHIESRPS RLNKDEYEFF TYLDKRTKPV LGSIIKSLRN DIGATVHELS RDKEKNTVPW
120 FPRTIQELDR FANQILSYGA ELDADHPGFK DPVYRARRKQ FADIAYNYRH GQPIPRVEYT
180 EEEKQTWGTV FRTLKALYKT HACYEHNHIF PLLEKYCGFR EDNIPQLEDV SQFLQTCTGF
240 RLRPVAGLLS SRDFLGGLAF RVFHCTQYIR HGSKPMYTPE PDICHELLGH VPLFSDRSFA
300 QFSQEIGLAS LGAPDEYIEK LATIYWFTVE FGLCKEGDSI KAYGAGLLSS FGELQYCLSD
360 KPKLLPLELE KTACQEYSVT EFQPLYYVAE SFSDAKEKVR TFAATIPRPF SVRYDPYTQR
420 VEVLDNTQQL KILADSINSE VGILCNALQK IKS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
823866
Dahl H.-H.M.,Mercer J.F.B.
Isolation and sequence of a cDNA clone which contains the complete coding region of rat phenylalanine hydroxylase. Structural homology with tyrosine hydroxylase, glucocorticoid regulation, and use of alternate polyadenylation sites.
J. Biol. Chem.
261
4148-4153
1986
823867
Wretborn M.,Humble E.,Ragnarsson U.,Engstrom L.
Amino acid sequence at the phosphorylated site of rat liver phenylalanine hydroxylase and phosphorylation of a corresponding synthetic peptide.
Biochem. Biophys. Res. Commun.
93
403-408
1980
823868
Robson K.J.H.,Beattie W.,James R.J.,Cotton R.C.H.,Morgan F.J.,Woo S.L.C.
Sequence comparison of rat liver phenylalanine hydroxylase and its cDNA clones.
Biochemistry
23
5671-5675
1984
823869
Nakata H.,Fujisawa H.
Purification and characterization of phenylalanine 4-monooxygenase from rat liver.
Biochim. Biophys. Acta
614
313-327
1980
823870
Lundby A.,Secher A.,Lage K.,Nordsborg N.B.,Dmytriyev A.,Lundby C.,Olsen J.V.
Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
Nat. Commun.
3
876-876
2012
823871
Kobe B.,Jennings I.G.,House C.M.,Michell B.J.,Goodwill K.E.,Santarsiero B.D.,Stevens R.C.,Cotton R.G.,Kemp B.E.
Structural basis of autoregulation of phenylalanine hydroxylase.
Nat. Struct. Biol.
6
442-448
1999