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EC Number
Protein Variants
Commentary
Reference
7.4.2.5
A123V
partial loss of uptake
719940
7.4.2.5
A264P
partial loss of uptake
719940
7.4.2.5
A285V
complete loss of uptake
719940
7.4.2.5
A303G
partial loss of uptake
719940
7.4.2.5
A68P
complete loss of uptake
719940
7.4.2.5
coreTAP1
mutant, delta2-122
686718
7.4.2.5
coreTAP2
mutant, delta2-122
686718
7.4.2.5
Cys-less
mutant for analyzing the interaction and regulatory domains of SecA
687527
7.4.2.5
D209A
a dominant-negative mutant, binds ATP but is unable to hydrolyze it and is inactive in proOmpA translocation. Mutant generates a translocation intermediate of 18 kDa. Further addition of wild-type SecA causes its translocation into either mature OmpA or another intermediate of 28 kDa that can be translocated into mature by a proton motive force. The addition of excess D209N SecA during translocation causes a topology inversion of SecG
720044
7.4.2.5
D209N
mutant of SecA capable of binding, but not hydrolysing ATP
688391
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