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Results 1 - 9 of 9
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EC Number Protein Variants Commentary Reference
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19H205A site-directed mutagenesis of the catalytic site residue, the mutant shows complete loss of epimerase activity 704498
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19H450A site-directed mutagenesis of the catalytic site residue, the mutant shows complete loss of epimerase activity 704498
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19more siRNA gene silencing of DS-epi2 and DS-epi1 in lung HFL-1 fibroblasts 704644
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19N183S site-directed mutagenesis of an N-glycosylation site in DS-epi1 altering reaction kinetics 704498
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19N336S site-directed mutagenesis of an N-glycosylation site in DS-epi1 altering reaction kinetics and reducing the activity 13fold 704498
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19N642S site-directed mutagenesis of an N-glycosylation site in DS-epi1 altering reaction kinetics 704498
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19N648S site-directed mutagenesis of an N-glycosylation site in DS-epi1 altering reaction kinetics and reducing the activity 43fold 704498
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19S268L a naturally occuring homozygous DSE mutation c.803C>T in a patient with musculocontractural type of Ehlers-Danlos syndrome, MCEDS. The mutant enzymes shows a loss of activity towards partially desulfated dermatan sulfate, patient-derived fibroblasts also show a significant reduction in epimerase activity 727608
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19Y261A site-directed mutagenesis of the catalytic site residue, the mutant shows complete loss of epimerase activity 704498
Results 1 - 9 of 9
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