EC Number   |
Protein Variants |
Reference |
|---|
   4.4.1.17 | C15A |
site-directed mutagenesis, cytoplasm-targeted mutant, the mutant is matured and undergoes heme attachment like the wild-type enzyme |
729740 |
| 4.4.1.17 | C15S |
the HCCS:cyt c C15S and C18A mutants support the formation of single thioether cross-links between the heme and cyt c at the vinyl position alternate to the mutation |
730058 |
| 4.4.1.17 | C18A |
site-directed mutagenesis, cytoplasm-targeted mutant, the mutant does not undergo heme attachment |
729740 |
| 4.4.1.17 | C18A |
the HCCS:cyt c C15S and C18A mutants support the formation of single thioether cross-links between the heme and cyt c at the vinyl position alternate to the mutation |
730058 |
| 4.4.1.17 | C26A |
site-directed mutagenesis of CP-motif 1 of the enzyme, the mutant shows activity similar to the wild-type enzyme |
729727 |
| 4.4.1.17 | C26A/C42A |
site-directed mutagenesis of both CP-motifs of the enzyme, the mutant shows activity similar to the wild-type enzyme |
729727 |
| 4.4.1.17 | C26A/P27A |
site-directed mutagenesis of CP-motif 1 of the enzyme, the mutant shows activity similar to the wild-type enzyme |
729727 |
| 4.4.1.17 | C42A |
site-directed mutagenesis of CP-motif 2 of the enzyme, the mutant shows activity similar to the wild-type enzyme |
729727 |
| 4.4.1.17 | C42A/P43A |
site-directed mutagenesis of CP-motif 2 of the enzyme, the mutant shows activity similar to the wild-type enzyme |
729727 |
| 4.4.1.17 | DELTA197-268 |
mutation identified in female patient with microphthalmia with linear skin defects syndrome. In contrast to wild-type, mutant protein is unable to complement a Saccharomyces cerevisiae mutant deficient in the yeast enzyme ortholog. Upon expression in CHO-K1 cells, mutant protein fails to be sorted to mitochondria. Mutation results in disturbance of both oxidative phosphorylation and the balance between apoptosis and necrosis |
677440 |
