EC Number   |
Protein Variants |
Reference |
|---|
    4.4.1.16 | C364A |
increased activity towards L-selenocysteine and L-cysteine sulfinate, activity toward L-cysteine was completely abolished |
645632 |
| 4.4.1.16 | C375A |
mutation on the catalytically essential Cys-375 residue |
704655 |
| 4.4.1.16 | D146K |
site-directed mutagenesis, the mutant variant shows loss of selenocysteine specificity and appearance of cysteine desulfurase activity |
730685, 730686 |
| 4.4.1.16 | D146K/H389T |
site-directed mutagenesis,the mutant variant shows loss of selenocysteine specificity and appearance of cysteine desulfurase activity to a higher extent |
730685, 730686 |
| 4.4.1.16 | H123A |
only 1% of activity remaining compared to wild type, contributes to stabilization of pyridoxal 5'-phospahte |
645630 |
| 4.4.1.16 | H389T |
site-directed mutagenesis, the mutant variant shows loss of selenocysteine specificity and appearance of cysteine desulfurase activity |
730686 |
| 4.4.1.16 | H55A |
no effect on activity |
645630 |
| 4.4.1.16 | more |
construction of enzyme knockout mice, phenotype, overview |
730381 |
| 4.4.1.16 | more |
HeLa cells transfected with enzyme-specific siRNA show decreased seleno-labeling efficiency of selenoproteins with selenoprotein P compared to the wild-type |
730241 |
| 4.4.1.16 | R379A |
less than 1% of activity remaining compared to wild type |
645630 |
