EC Number   |
Protein Variants |
Reference |
|---|
    4.2.3.12 | C10A |
50% decrease in activity |
664165 |
| 4.2.3.12 | C42A |
no catalytic activity, complete loss of metal binding site and activity, it is the only Cys in the active site |
648554 |
| 4.2.3.12 | D96N |
mutant enzyme that causes PTPS deficiency |
648575 |
| 4.2.3.12 | Delta1-11 |
Flag-tag fused PTPS with N-terminal deletion, 97% decrease in activity |
664165 |
| 4.2.3.12 | DELTA119-145 |
Flag-tag fused PTPS with C-terminal deletion, no detectable activity, no more nuclear staining |
664165 |
| 4.2.3.12 | DELTA143-145 |
Flag-tag fused PTPS with C-terminal deletion, no detectable activity, no more nuclear staining |
664165 |
| 4.2.3.12 | DELTAV57 |
mutant enzyme DELTAV57 is incorrectly folded and thus unstable |
648563 |
| 4.2.3.12 | E133Q |
1.3% of wild-type activity but similar affinity for the substrate |
648554 |
| 4.2.3.12 | H23L |
complete loss of metal binding site and activity |
648554 |
| 4.2.3.12 | H48L |
complete loss of metal binding site and activity |
648554 |
