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EC Number Protein Variants Commentary Reference
Display the reaction diagram Show all sequences 4.2.1.168H188K mutant protein cannot catalyze the dehydration step 738573
Display the reaction diagram Show all sequences 4.2.1.168H188K the active site histidine has been replaced with a lysine. The electron density reveals that the geminal diamine, a tetrahedral intermediate in the formation of pyridoxamine 5'-phosphate from pyridoxal 5'-phosphate, has been trapped within the active site region 737666
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