EC Number   |
Protein Variants |
Reference |
|---|
   3.6.4.B1 | more |
in KIF14 depleted cells, citron kinase but not other components of the central spindle and cleavage furrow fail to localize. Localization of KIF14 and citron kinase to the central spindle and midbody is codependent, they form a complex depending on the activation state of citron kinase |
687900 |
| 3.6.4.B1 | more |
overexpression of KIFC5A in mouse cells causes the formation of aberrant, non-separated microtubule asters and mitotic arrest in a prometaphase-like state. KIFC5A knockdown partly rescues the phenotype caused by inhibition of plus-end directed motor Eg5 by monastrol on the mitotic spindle. Silencing also results in centrosome amplification detectable throughout the cell cycle. KIFC5A interacts with nucleotide-binding proteins 1 and 2. Knockdown of nucleotide-binding protein 1 or double knockdown of nucleotide-binding proteins 1 and 2 both phenocopy the KIFC5A silencing effect |
687910 |
| 3.6.4.B1 | Q101C |
modification in loop L5 and labeling of mutant Cys residue with 2-(4'-(2''-iodoacetamido)phenyl)aminonaphthalene-6-sulfonic acid. In the absence of nucleotides, label is incorporated at almost equimolar ratio into loop L5. In the presence of ATP and ADP, the incorporated amount is reduced to 0.62 and 0.32 mol label per mol of motor domain, respectively |
687438 |
| 3.6.4.B1 | T93N |
rigor-mutant, binds to microtubules but fails to move along them |
687916 |
