EC Number |
Protein Variants |
Reference |
---|
3.6.1.52 | C214S |
inactive |
-, 757172 |
3.6.1.52 | E66Q |
no significant activity towards diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate, activity with diadenosine 5',5'''-P1,P6-hexaphosphate is 2% of the activity of the wild-type enzyme |
393826 |
3.6.1.52 | E70Q |
- |
393824 |
3.6.1.52 | E70Q |
greatly reduced rate of hydrolysis of diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate |
393824 |
3.6.1.52 | E70Q |
inactive against dATP,diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate |
393826 |
3.6.1.52 | F84Y |
hydrolysis of bisdiphosphoinositol tetrakisphosphate at 63% of the activity of the wild-type enzyme, hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate is 75% of the activity of the wild-type enzyme, activity with diphosphoinositol pentakisphosphate is only slightly reduced |
393826 |
3.6.1.52 | G50A |
hydrolysis of diphosphoinositol polyphosphates is more than 85% less than that of the wild-type enzyme |
393826 |
3.6.1.52 | G52A |
hydrolysis of diphosphoinositol polyphosphates is more than 85% less than that of the wild-type enzyme |
393826 |
3.6.1.52 | G72A |
catalytic activity towards bisdiphosphoinositol tetrakisphosphate, diadenosine 5',5'''-P1,P6-hexaphosphateand diphosphoinositol pentakisphosphate is impaired by more than 95% |
393826 |
3.6.1.52 | G75A |
catalytic activity towards bisdiphosphoinositol tetrakisphosphate, diadenosine 5',5'''-P1,P6-hexaphosphateand diphosphoinositol pentakisphosphate is impaired by more than 95% |
393826 |