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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.42more construction of s disruption mutant showing defects in N-glycosylation of other proteins 655628
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.42more disruption of gene gda1 leads to a mutant with 90% reduced GDP hydrolysis activity compared to the wild-type, the mutant also shows severely impaired O-mannosylation and reduced cell wall phosphate content and other phenotypes, but the formation of hyphae is uneffected, overview 655389
Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.42more enzyme null mutants show 95% reduced activity in vitro and inhibition of glycosyltransferases utilizing uridine and guanosine nucleotide sugars due to accumulation of nucleoside diphosphates, the transport of both GDP-mannose and UDP-GlcNAc into the Golgi lumen is reduced in the null mutants, complementation of the disruption mutant by recombinant expression of the wild-type enzyme or the Saccharomyces cerevisiae enzyme 488582
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