EC Number   |
Protein Variants |
Reference |
|---|
   3.5.4.B9 | C243A/C321A/C356A |
the mutation has no effect on localization, deamination, oligomerization, or HIV-1 Vif-deficient restriction capabilities. The mutant is only partially resistant to inhibitor MN256.0105, with recovered deamination efficiency of 19% |
722064 |
| 3.5.4.B9 | C288A/C291A |
the mutant enzyme shows about 18% activity compared to the wild type enzyme |
723260 |
| 3.5.4.B9 | C321A |
the mutation has no effect on localization, deamination, oligomerization, or HIV-1 Vif-deficient restriction capabilities. The mutant is only partially resistant to inhibitor MN256.0105, with recovered deamination efficiency of 21% |
722064 |
| 3.5.4.B9 | C97A/C100A |
the mutant enzyme shows about 18% activity compared to the wild type enzyme |
723260 |
| 3.5.4.B9 | D264A |
5.1% of wild-type activity |
754123 |
| 3.5.4.B9 | D264A |
5.1% of wild-type activtiy |
754123 |
| 3.5.4.B9 | D264A |
the variant has 5% of the catalytic efficiency of the wild type protein |
734319 |
| 3.5.4.B9 | D316R/D317R |
the mutant shows about 180% deamination activity and about 200% single-stranded DNA binding compared to the wild type enzyme |
723261 |
| 3.5.4.B9 | D316R/D317R |
the mutations increase affinity for substrate and deamination specificity |
722665 |
| 3.5.4.B9 | D370A |
15.8% of wild-type activity |
754123 |
