EC Number   |
Protein Variants |
Reference |
|---|
    3.5.1.42 | C32A |
site-directed mutagenesis, the mutant shows 28% reduced activity compared to the wild-type enzyme |
755141 |
| 3.5.1.42 | E28A |
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme |
733870 |
| 3.5.1.42 | K61Q |
site-directed mutagenesis, inactive mutant |
733870 |
| 3.5.1.42 | K638A |
site-directed mutagenesis, inactive mutant |
755141 |
| 3.5.1.42 | more |
construction of a TK1650 knockout mutant strain |
-, 754020 |
| 3.5.1.42 | more |
NMN deamidase blocks Wallerian degeneration in transgenic zebrafish larvae. NMN deamidase also rescues axonal outgrowth and perinatal lethality in a dose-dependent manner in mice lacking NMNAT2. Recombinant NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo. NMN deamidase protection is neuron specific and effective against various toxic insults. NMN deamidase expression confers morphological and functional preservation of transected axons |
753342 |
| 3.5.1.42 | R142A |
site-directed mutagenesis, inactive mutant |
733870 |
| 3.5.1.42 | R145A |
site-directed mutagenesis, inactive mutant |
-, 755141 |
| 3.5.1.42 | S103A |
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme |
733870 |
| 3.5.1.42 | S29A |
site-directed mutagenesis, inactive mutant |
733870 |
