EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.89 | E143A |
18% of wild-type activity |
-, 735291 |
| 3.4.24.89 | E143A |
mutant displays highly reduced activity on fibronectin, binding of Zn2+ is similar to wild-type |
-, 728634 |
| 3.4.24.89 | E143A/Y178F |
complete loss of activity |
-, 735291 |
| 3.4.24.89 | E143A/Y178F |
inactive |
-, 754181 |
| 3.4.24.89 | E184A |
the mutant shows reduced activity for Abz-DVVNPPVPPSKDD-CONH2 (15%) and Abz-DVVNAPVPPSKDD-CONH2 (9%) and residual activity for Abz-DVVNPAVPPSKDD-CONH2 (1.2%) compared to the wild type enzyme |
-, 754181 |
| 3.4.24.89 | E184K |
the mutant shows residual activity compared to the wild type enzyme |
-, 754181 |
| 3.4.24.89 | H146A |
complete loss of the ability to bind Zn2+, highly reduced activity on fibronectin |
-, 728634 |
| 3.4.24.89 | K101A |
the mutant shows dramatically reduced activity compared to the wild type enzyme |
754181 |
| 3.4.24.89 | K101E |
the mutant shows dramatically reduced activity compared to the wild type enzyme |
754181 |
| 3.4.24.89 | K101R |
the mutant shows about wild type activity |
-, 754181 |
