EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.81 | C173S |
mutation does not impair the inhibitory potency of the ADAM10 prodomain against ADAM10 |
680854 |
| 3.4.24.81 | DELTA672 |
a truncated soluble construct of ADAM10 lacking the transmembrane and cytosolic domains (truncation after Glu680), although correctly post-translationally processed and catalytically active with respect to a synthetic peptide substrate, is incapable of shedding cell-associated amyloid precursor protein (APP) |
699655 |
| 3.4.24.81 | E384A |
the point mutation which compromises the zinc-binding consensus motif, leads to a substantial decrease in amyloid precursor protein-alpha secretion |
708492 |
| 3.4.24.81 | E385A |
inactive |
680772 |
| 3.4.24.81 | more |
a GPI-anchored form of ADAM10 lacking the cytosolic, transmembrane and a-helical juxtamembrane regions of the wild-type protein is shed in a similar manner. Mutant fusion construct consists of the first 652 residues of wild-type ADAM10 fused, via a two residue linker, to the 24 residue GPI anchor signal sequence of human carboxypeptidase M |
699655 |
| 3.4.24.81 | more |
ADAM10 mutant lacking the prodomain is inactive, the prodomain is probably involved in the maturation of the enzyme |
644072 |
| 3.4.24.81 | more |
consensus sequence RKKR mutated for NAQA resulting in no expression of mature protein |
644072 |
| 3.4.24.81 | more |
in ADAM10 deficient mouse embryonic cells the constitutive release of soluble epidermal growth factor and also beta-cellulin is strongly reduced when compared with wild type controls and can be reintroduced by adding of wild type ADAM10. Overexpression of ADAM10 causes an increase in beta-cellulin shedding, whereas the overexpression of catalytically inactive ADAM10 decreases the beta-cellulin shedding |
679356 |
| 3.4.24.81 | more |
in vivo investigations of mice overexpressing either ADAM10 or dominant negative ADAM10 show unaltered cleavage of neuregulin-1 compared to wild-type animals. As a consequence, the myelin sheath thickness of peripheral nerves is unaffected in mice with altered ADAM10 activity |
697898 |
| 3.4.24.81 | more |
increased ADAM10 expression is functionally associated with an increase in endothelial permeability. ADAM10 activity also contributes to the thrombin-induced decrease of endothelial cell-cell adhesion |
697352 |
