EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.79 | E483A |
a proteolytically inactive PAPP-A mutant |
683645, 683675 |
| 3.4.24.79 | E483Q |
active-site mutant |
733391 |
| 3.4.24.79 | E483Q |
he proteolytic activity of the mutant is markedly reduced |
719372 |
| 3.4.24.79 | more |
a mutant chimeric variant of PAPP-A, which is replaced in part by PAPP-A2 sequences, retains functionality as a protease but is unable to bind surface-associated glycosaminoglycan and shows no macrophage association or internalization |
683050 |
| 3.4.24.79 | more |
construction of chimeras between PAPP-A and PAPP-A2 of human and murine sequences, overview |
683675 |
| 3.4.24.79 | more |
construction of enzyme knockout mice, dwarf phenotype with decreased body size and IGF-II deficiency, overview |
683504 |
| 3.4.24.79 | more |
construction of PAPP-A knockout mice, which show impaired post-fracture, bony bridging of a mid-shaft fracture callus, the mutant mice show reduced amount of intramembranous bone formation, cartilage production, endochondral ossification and remodeling compared to wild-type mice, overview |
683711 |
| 3.4.24.79 | more |
construction of transgenic mice overexpressing the enzyme, osteoblasts of transgenic mice show increased IGFBP-4 proteolysis and increased free IGF-I concentration. Calvarial bone thickness, bone marrow cavity, and skull bone mineral density are significantly increased in transgenic mice, bone size-related parameters in femur and tibia such as total bone area and periosteal circumference are significantly increased in transgenic mice. Bone formation rate and osteoid surface are increased by more than 2fold, whereas bone resorbing surface is unaffected. These anabolic effects are sustained with aging, phenotype overview |
683411 |
| 3.4.24.79 | more |
PAPP-A overexpression in transgenic mice leads to increased somatic groath and skeletal muscle mass, phenotype, overview |
683415 |
