EC Number   |
Protein Variants |
Reference |
|---|
   3.4.23.48 | D206A |
1.3% of wild-type plasminogen activation |
638924 |
| 3.4.23.48 | D206A |
proteolytic activity is abolished |
638923 |
| 3.4.23.48 | D206A |
site-directed mutagenesis, introducing the single point mutation into the active site of Pla suffices to render fully virulent Yersinia pestis susceptible to primed T-cells. The protective capacity of YopE-specific CD8 T cells against CO92 Pla-D206A is abrogated in mice with low levels of tissue factor activity as well as in PAI-1/TAFI double knockout mice. In addition, YopE-specific CD8 T cells poorly protect wild-type mice treated with Coumadin, a pharmacologic anticoagulant that reduces production of fibrin |
-, 753803 |
| 3.4.23.48 | D212R |
111% of wild-type plasminogen activation |
638924 |
| 3.4.23.48 | D84A |
3.7% of wild-type plasminogen activation |
638924 |
| 3.4.23.48 | D86A |
3.5% of wild-type plasminogen activation |
638924 |
| 3.4.23.48 | D86A |
inactive, crystallization data |
718407 |
| 3.4.23.48 | D97A |
56% of wild-type plasminogen activation |
638924 |
| 3.4.23.48 | E217S |
52% of wild-type plasminogen activation |
638924 |
| 3.4.23.48 | F215Y |
42% of wild-type plasminogen activation |
638924 |
