EC Number   |
Protein Variants |
Reference |
|---|
   3.4.22.B79 | A662T |
temperature-sensitive in vivo and in vitro |
679819 |
| 3.4.22.B79 | C478A |
complete loss of activity |
755486 |
| 3.4.22.B79 | C478A |
inactive |
679819 |
| 3.4.22.B79 | C478A |
mutation in active site, loss of activity |
-, 753844 |
| 3.4.22.B79 | C478A |
residue Cys478 in the active site of CHIKV nsP2 is indispensable for polyprotein P1234 processing. Mutation completely abolishes RNA replication trans-replication systems and abolishes the rescue of infectious virus from CHIKV RNA transcripts |
-, 755448 |
| 3.4.22.B79 | C478A |
significantly less activity than wild type for the 2-(N-methylamino)benzoyl-AGAGIIETk(Dnp)substrate |
-, 755412 |
| 3.4.22.B79 | C481G |
mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal |
29849 |
| 3.4.22.B79 | C481R |
mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal |
29849 |
| 3.4.22.B79 | C481S |
mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal |
29849 |
| 3.4.22.B79 | C525R |
mutation in C-terminal protease domain, abolishes catalytic activity, and is lethal |
29849 |
