EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.42 | C1s(MASP-2 CCP1/2) |
chimeric C1s protease containing the MASP-2 complement control protein domain, cleavage efficiency of C4 similar to MASP-2 protease |
665686 |
| 3.4.21.42 | C1s(MASP-2 SP) |
chimeric C1s protease containing the MASP-2 serine protease domain, cleavage efficiency similar to wild-type C1s |
665686 |
| 3.4.21.42 | C294R |
the mutation is associated with periodontal Ehlers-Danlos syndrome |
752432 |
| 3.4.21.42 | D275S/P276I/K405V |
similar to wild-type C1s |
665686 |
| 3.4.21.42 | D343N |
complement component C4 cleavage activity below 50% compared to wild-type, complement component C2 cleavage activity similar to wild-type |
669727 |
| 3.4.21.42 | G630E |
missense mutation, like normal C1s, the mutant has the ability to form a complex with rC1r. The activity of the mutant is significantly lower than that of wild-type, being only 60% of the activity of the wild-type rC1s. The mutant has a higher susceptibility to proteolysis than the wild-type, and prolonged proteolysis generates a truncated L chain with little or no protease activity |
699344 |
| 3.4.21.42 | K628A |
the mutant shows lower activity than wild-type enzyme against peptide substrates, cleavage of C4 is reduced by 5fold compared to the wild-type enzyme |
731865 |
| 3.4.21.42 | K628Q |
the mutant shows greater activity than wild-type enzyme against peptide substrates and peptide substrates containing physiological substrate sequences, unaltered activity with 2-aminobenzoyl-GLQRALEI-Lys(dinitrophenol)-NH2 substrate compared to the wild-type enzyme, but cleavage of C4 complement is reduced by 5fold compared to the wild-type enzyme |
731865 |
| 3.4.21.42 | more |
only the fragment bearing the serine protease (SP) and the complement control protein (CCP) module 2 of MASP-2 were expressed and crystallized |
659718 |
| 3.4.21.42 | P341I |
complement component C4 cleavage activity below 50% compared to wild-type, complement component C2 cleavage activity similar to wild-type |
669727 |
