EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.20 | A226E |
the missense mutation creates tryptic activity in human cathepsin G |
717936 |
| 3.4.21.20 | A226E |
the mutant of mouse cathepsin G acquires tryptic activity and human ability to activate prourokinase |
717936 |
| 3.4.21.20 | A226E |
the substitution at the bottom of the cathepsin G S1 pocket allows cathepsin G to accommodate a Lys residue at P1 |
717592 |
| 3.4.21.20 | more |
acute inflammatory response components are decreased by more than 50% in kidneys from cathepsin G-deficient versus wild-type mice, ischemic kidneys from cathepsin G-deficient mice have a 70% decrease in tubular cell apoptosis with little detectable collagen deposition, phenotypes, overview |
683042 |
| 3.4.21.20 | more |
no increased cytokine production and increased bacterial reduction by phagocytosis in infected lungs of enzyme-deficient mice compared to wild-type mice, overview |
683957 |
| 3.4.21.20 | more |
when microglia are treated with interferon-gamma to mimic a T helper type 1-biased cytokine milieu in multiple sclerosis, CatG is drastically down-regulated resulting in significantly increased stability of myelin basic protein and a selective lack of CatG-derived proteolytic fragments |
683531 |
| 3.4.21.20 | S189A/A226E |
the mutant shows decreased catalytic efficiency compared to the wild type enzyme and develops Lys-thioesterase activity |
717936 |
