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Results 1 - 10 of 11 > >>
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11D141A substitution leads to a decrease in expression level (compared to wild type). Melting temperature is 53.2°C, compared to 60.4°C for wild-type enzyme 753264
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11E175A substitution leads to a decrease in expression level (compared to wild type). Melting temperature is 71.4°C, compared to 60.4°C for wild-type enzyme. Mutation abolishes activity against methotrexate 753264
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11E200A substitution leads to a decrease in expression level (compared to wild type). Melting temperature is 64.3°C, compared to 60.4°C for wild-type enzyme 753264
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11G123S the variant has increased catalytic efficiency relative to wild type enzyme. The mutant enzyme has higher alpha-helical content relative to the wild type enzyme 752914
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11H112A substitution leads to a high decrease in expression level (compared to wild type). Melting temperature is 28.2°C, compared to 60.4°C for wild-type enzyme 753264
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11H385A substitution leads to a low decrease in expression level (compared to wild type). Melting temperature is 55.1°C, compared to 60.4°C for wild-type enzyme 753264
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11I100T the variant has increased catalytic efficiency relative to wild type enzyme. The mutant enzyme has higher alpha-helical content relative to the wild type enzyme 752914
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11K208A substitution leads to a high decrease in expression level (compared to wild type). Melting temperature is 53.4°C, compared to 60.4°C for wild-type enzyme. Mutation abolishes activity against methotrexate 753264
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11S210A substitution leads to a high decrease in expression level (compared to wild type). Melting temperature is 54.4C, compared to 60.4°C for wild-type enzyme. Mutation abolishes activity against methotrexate 753264
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.11T239A the variant has increased catalytic efficiency relative to wild type enzyme. The mutant enzyme has higher alpha-helical content relative to the wild type enzyme 752914
Results 1 - 10 of 11 > >>
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