EC Number   |
Protein Variants |
Reference |
|---|
   3.1.3.95 | A253K |
the mutation enhances the kcat/Km value by 49% compared to the wild type enzyme |
749489 |
| 3.1.3.95 | C338S |
inactive |
749489 |
| 3.1.3.95 | C375S |
complete loss of activity |
665599 |
| 3.1.3.95 | C413S |
catalytically inactive mutant. Overexpression of a catalytically dead MTMR3 (C413S) in mammalian cells induces a striking formation of vacuolar compartments that enclose membranous structures that are highly concentrated in mutant proteins |
724804 |
| 3.1.3.95 | C413S |
inactive |
750542 |
| 3.1.3.95 | C413S |
mutant without catalytic activity, mutant is unable to rescue the RNAi-knockdown phenotype, indicating that isoform MTMR3 acts enzymatically on phosphoinositides during cell migration |
727365 |
| 3.1.3.95 | C438S |
inactive |
751944 |
| 3.1.3.95 | D443A |
almost inactive |
751944 |
| 3.1.3.95 | DELTAF494-E531 |
recessive Charcot-Marie-Tooth disease type 4B1 related mutation, almost complete loss of activity |
727605 |
| 3.1.3.95 | E276X |
recessive Charcot-Marie-Tooth disease type 4B1 related mutation, almost complete loss of activity |
727605 |
