EC Number |
Protein Variants |
Reference |
---|
3.1.3.67 | 380-385A |
in endothelial cells transfected with 380-385A (mutation on the PTEN phosphorylation site) phosphatidylinositol 3,4,5-trisphosphate immunofluorescence intensity is than in wildtype or G129R transfected cells. Phosphatidylinositol 3,4,5-trisphosphate intensity in endothelial cells transfected with 380385A is weak but gradually increases to a maximum at 240 min after cyclic strain stimulation by 1.48fold relative to static condition |
681020 |
3.1.3.67 | A121P |
inactive mutant enzyme |
650767 |
3.1.3.67 | C105F |
inactive mutant enzyme |
650767 |
3.1.3.67 | C124R |
inactive mutant enzyme |
650767 |
3.1.3.67 | C124S |
adenovirus encoding a dominant negative human PTEN cDNA is used for the transduction of cell cultures |
692556 |
3.1.3.67 | C124S |
catalytically inactive mutant enzyme |
650763 |
3.1.3.67 | C124S |
catalytically inert mutant enzyme |
653626 |
3.1.3.67 | C124S |
complete loss of activity towards inositol 1,3,4,5-tetrakisphosphate |
651881 |
3.1.3.67 | C124S |
mutant PTEN-C124S-A4-YFP lacks lipid and protein phosphatase activity, great localization to the plasma membrane than other mutants |
694916 |
3.1.3.67 | C124S |
phosphatase-deficient |
705669 |