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Results 1 - 7 of 7
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.52A193X single-nucleotide polymorphisms (SNPs) in human PP2Cm: mutant demonstrate basal activity against branched-chain alpha-keto dehydrogenase (BCKD) but impaired responsiveness to branched-chain-alpha-keto acids (BCKAs) 732061
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.52E321K single-nucleotide polymorphisms (SNPs) in human PP2Cm: mutant demonstrate basal activity against branched-chain alpha-keto dehydrogenase (BCKD) but impaired responsiveness to branched-chain-alpha-keto acids (BCKAs). Mutant is not detected by immunoblot using human PP2Cm antibody. Therefore, it remains unclear whether this mutant is phosphatase dead due to loss-of-function mutations or unstable due to premature truncation 732061
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.52F359X single-nucleotide polymorphisms (SNPs) in human PP2Cm: frameshift mutant shows no phosphatase activity at basal or after branched-chain-alpha-keto acids (BCKA) treatment. Mutant is not detected by immunoblot using human PP2Cm antibody. Therefore, it remains unclear whether this mutant is phosphatase dead due to loss-of-function mutations or unstable due to premature truncation 732061
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.52I167T single-nucleotide polymorphisms (SNPs) in human PP2Cm: mutation has no an elevated activity compared to wild-type 732061
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.52more motifs responsible for PP2Cm and E2 interaction: using deletion mutants it is shown that the region between the residues 46 and 61 is critical to the association of PP2Cm with the complex 732061
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.52N94K missense mutant due to single nucleotide polymorphism. Mutation significantly impairs Mg2+-dependent catalytic activity and induces a conformational change in the key residue in coordinating the Mg2+ in the active site 751367
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.52N94K single-nucleotide polymorphisms (SNPs) in human PP2Cm: mutation has no impact on PP2Cm activity 732061
Results 1 - 7 of 7